Journal of Otology & RhinologyISSN: 2324-8785

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Case Report, J Otol Rhinol Vol: 4 Issue: 5

Invasive Rhinocerebral Mycosis: A report of three cases from India

Malhotra S*, Sharma S, Bhatia NJK and Hans C
Department of Microbiology, Dr. Ram Manohar Lohia Hospital and PGIMER, New Delhi, India
Corresponding author : Dr Shalini Malhotra
Department of Microbiology, PGIMER & Dr. RML Hospital, New Delhi- 110001
Tel: 9810778233
Received: July 11, 2015 Accepted: September 03, 2015 Published: September 07, 2015
Citation: Malhotra S, Sharma S, Bhatia NJK, Hans C (2015) Invasive Rhinocerebral Mycosis: A report of three cases from India. J Otol Rhinol 4:5. doi:10.4172/2324-8785.1000246


Rhinocerebral mycosis is a rapidly progressive fatal opportunistic infection and is increasingly being recognized these days. Aspergillosis and zygomycosis are predominantly responsible for rhinocerebral mycosis. Here we are presenting three cases of rhinocerebral mycosis- two cases of rhinocerebral mucormycosis and one case of rhinocerebral aspergillosis. Diagnosis is established presumptively from fungal culture of sinus or nasal material and tissue biopsy for histopathological examination. MRI brain was done in all the three cases which showed extension of disease in the cavernous sinus (case 1), orbit and peri-orbital region (case 2) and frontal lobe (case 3). Amphotericin B was initiated in all the cases, while surgical debridement was done in the 3rd case. However two out of three cases were succumbed to their illness after 10-12 days of admission, suggesting high mortality in such cases.

Keywords: Mycosis; Rhinocerebral; Amphotericin B

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