Journal of Womens Health, Issues and Care ISSN: 2325-9795

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Research Article, J Addict Behav Ther Rehabil Vol: 4 Issue: 5

Knowledge of HPV among HIV-Infected and HIV-Uninfected Adolescent Women in South Africa

David C. Griffith1*, David Adler2, Melissa Wallace3, Thola Bennie3, Beau Abar2 and Linda-Gail Bekker3
1Department of Internal Medicine and Pediatrics, University of Rochester, Rochester NY, USA
2601 Elmwood Avenue, Box 655, Department of Emergency Medicine, University of Rochester, Rochester, NY, 14534, USA
3Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa
Corresponding author : David C. Griffith, MD
Johns Hopkins Hospital, 200 N. Wolfe Street, Rm 3155, Baltimore, MD 21287, USA
Tel: 410-614-3917; Fax: 410-614-1491
E-mail: [email protected]
Received: April 29, 2015 Accepted: September 21, 2015 Published: September 23, 2015
Citation: Griffith DC, Adler D, Wallace M, Bennie T, Abar B, et al. (2015) Knowledge of HPV among HIV-Infected and HIV-Uninfected Adolescent Women in South Africa. J Womens Health, Issues Care 4:5. doi:10.4172/2325-9795.1000203

Abstract

Knowledge of HPV among HIV-Infected and HIV-Uninfected Adolescent Women in South Africa

Objective: The aim of this study is to examine the knowledge of human papillomavirus (HPV) and cervical cancer among HIVinfected and HIV-uninfected female adolescents in South Africa. Methods: Subjects were recruited from a parent study of HPV infection comprised of females ages 16-21 in Masiphumelele, Cape Town, South Africa. A total of 30 subjects, 15 HIV-infected and 15 HIV-uninfected, were selected via randomization and completed a measure of HPV knowledge, based on a previously validated instrument. The study took place in May 2013. Results: The overall mean score on the measure for all subjects was 43.3% (S.D. 10.9). There was no significant difference in HPV knowledge between the HIV-infected and HIV-uninfected groups. Based on results from a previous large-scale study using the same validated measure, this sample scored significantly worse on general HPV knowledge than samples from the US, UK, and Australia. Conclusion: Given the limited knowledge of HPV in this sample, there is greater need for education about the prevention of cervical cancer, specifically among high-risk adolescent women.

Keywords: HPV; HIV; Adolescent; South Africa; Knowledge; Vaccine; Cervical Cancer

Keywords

HPV; HIV; Adolescent; South Africa; Knowledge; Vaccine; Cervical Cancer

Introduction

Cervical cancer is the most common cause of cancer related death among woman in Southern Africa [1]. It has been shown that in South Africa, HIV-infected women have an increased risk of cervical cancer when compared to HIV-uninfected women [2]. HIV-infected women are more likely than their HIV-uninfected counterparts to have persistent infections with the human papillomavirus (HPV) genotypes that are high risk for the development of cervical cancer [3,4]. Given this increased risk, it is important that HIV-infected women are aware of HPV and the importance of routine screening to prevent cervical cancer. A recent review article shows that, overall the knowledge about HPV and cervical cancer in Sub Saharan Africa, including South Africa, is very low [5].
Understanding a population’s knowledge about HPV and cervical cancer prevention is essential to planning and implementing public health education and cervical cancer prevention efforts. There is a paucity of literature addressing the knowledge of HPV among HIV-infected adolescent women in South Africa. In order to target this high-risk population with cervical cancer prevention efforts, it is important to understand their baseline knowledge. We used a validated measure to assess and compare HPV knowledge between HIV-infected and HIV-uninfected South African adolescent females.

Methods

Participants were recruited as a subgroup from an ongoing parent study of HPV infection among HIV-infected and HIV-uninfected women ages 16-21 in Masiphumelele, a township south of Cape Town. In order to form our sub-study cohort, all participants in the parent study were divided into two subgroups, HIV-infected and HIV-uninfected. Fifteen participants from each group were randomly selected to participate in a measure of HPV knowledge. The measure was a one-time assessment of participants’ knowledge and took place after enrollment in the study.
The measure of HPV knowledge was independently completed in writing by each participant, however participants were read aloud each question by a study coordinator in small groups of 5-10. The measure was available in both English and Xhosa. Each question had an option of true, false, or don’t know. A response of “don’t know” was coded as incorrect as it indicated lack of knowledge regarding item content. The measure was comprised of questions from a validated instrument of awareness of HPV, HPV testing, and HPV vaccination [6]. In addition to the validated measure, questions on prior HPV knowledge and Pap test knowledge were added (Appendix A). The measure consisted of the following subsections: Prior HPV knowledge, HPV Knowledge, HPV testing, HPV vaccination, Pap test knowledge, and Vaccine acceptance. Prior HPV knowledge was based on participants personal reflection of their of pre-enrollment awareness of HPV and cervical cancer. This study was approved by Research Subjects Review Board at the University of Rochester and the Research Ethics Committee at the University of Cape Town.
Statistical Analysis
Data analysis was conducted using SPSS 21 (IBM, 2012). Continuous values (i.e., percentage correct) were presented as means and standard deviations, and independent samples t-tests were used to compare means in the HIV-infected and HIV-uninfected groups. Paired samples t-tests were used to compare means across measure subsections. Finally, one sample t-tests were used to compare observed scores versus established rates from prior large-scale research.

Results

The measure was completed by a total of 30 participants, 15 HIV-infected and 15 HIV-uninfected. The mean age was 19 and the mean education level was grade 10. Overall, the mean score based on correct answers was 43.4% (S.D. =10.9). There was no difference in total knowledge of HPV between the two groups (M HIV + = 41.8%, S.D. = 8.8; M HIV - = 45.1%, S.D. = 12.8). Both groups were similar in awareness of the terms HPV and cervical cancer prior to enrolling in the study (M HIV + = 0.58; M HIV - = 0.60). A comparison of results by sub-topic for the study groups is provided in Table 1.
Table 1: Mean knowledge score and standard deviation by subtopic among HIVinfected and HIV-uninfected adolescent woman ages 16-21 in Masiphumelele, Cape Town, South Africa.
For each subtopic, there was no significant difference in performance based on HIV status. Despite relatively low mean scores in general HPV knowledge, the group performed well on some individual questions. Overall, 90% (27/30) of participants correctly answered that a person could have HPV without knowing it. Also, 77% (23/30) correctly answered that HPV can be passed by sexual intercourse and that having many sexual partners increases the risk of HPV. However, only 3% (1/30) correctly answered that HPV usually does not need treatment. This type of bifurcation in answering patterns is primarily responsible for low internal consistency of this subscale within this population (α = 0.52).
With regards to the HPV test knowledge, the HIV negative group performed better than the HIV positive group, though the difference was not significant. Within this sub-topic, 97% (29/30) of the sample incorrectly answered that a HPV testing is used to determine if an HPV vaccine is needed.
Performance on HPV vaccine questions was poorer than the other subtopics. Specifically, scores regarding the HPV vaccine were moderately lower than scores regarding general HPV knowledge, t(29)=2.28, p=0.03. Importantly, however, 63% (19/30) of the participants would be willing to get a vaccine that prevents cervical cancer if it was free or at low cost.
There was greater knowledge of Pap tests compared to the other topics in the survey (Table 1). Specifically, scores regarding Pap tests were significantly higher than scores regarding general HPV knowledge (t(29) =2.17, p=0.04), HPV test (t (29) =3.96, p<0.001), and HPV vaccine (t(29)=4.37, p<0.001). Oveall, 80% (24/30) correctly identified that a Pap smear is used to test for cervical cancer.
Follow-up bivariate analyses did not reveal and significant Spearman correlations (p’s > 0.05) between performance on the knowledge measure subsections and age or education level.
Finally, we sought to compare the overall performance of the current sample to that observed in previous large-scale, international research using the same validated instrument [7]. Results showed this sample of South African females scored significantly worse on general HPV knowledge than samples from the United States (61%; t (29) = -6.44, p<0.001), United Kingdom (57%; t (29) = -4.69, p<0.001), and Australia (55%, t(29)=-4.12, p<0.001).

Discussion

The results of this study indicate that knowledge of HPV amongst these South African adolescent women was very limited. Recent studies of South African women have shown a low level of knowledge of HPV and its relationship to cervical cancer based on analysis of data from focus groups [8,9]. Similarly, a study utilizing survey methods demonstrated a low level of knowledge of HPV, HPV vaccination, and cervical cancer among 18-44 year old women [10]. While our results are consistent with these prior studies, these studies did not specifically focus on the awareness among adolescent women or highrisk HIV-infected women. A prior survey based study did focus on undergraduate women and demonstrated a low level of awareness and knowledge of HPV and cervical cancer screening, but did not address the HIV status of the population [11]. Our study is unique in addressing awareness in the high-risk adolescent HIV-infected population using a validated measure.
We found no statistical difference in knowledge between the HIV-infected and HIV-uninfected participants. This was unexpected given that the national guidelines in South Africa call for routine cervical cancer screening for all HIV-infected women regardless of age [12] while screening begins at age 30 for HIV-uninfected women [13]. Also, those with HIV are more likely to be engaged in the health care system and therefore might be expected to have more general knowledge. However, this result is consistent with studies showing that cervical cancer screening rates for HIV-infected women are low in South Africa despite the national guidelines, with one study in Cape Town finding only 13% of women had at least one Pap smear after diagnosis with HIV [14]. Cervical cancer screening rates among the general population in South Africa have been estimated at only 20% in a multicenter national study [15].
Though overall knowledge was poor, performance was high for some specific questions. A majority of participants correctly identified that HPV is sexually transmitted and that risk is increased with increasing number of sexual partners. The highest score of any individual question was that a person could have HPV without knowing it, which is encouraging for potential acceptance of screening programs. The overall acceptance of a vaccination is also encouraging, especially in light of a recent study that reported high acceptability and successful uptake of HPV vaccination among school-age girls in South Africa [16].
The disparity between the levels of knowledge of our study participants compared with results in resource rich countries also highlights the need for better education about cervical cancer prevention, especially among populations at highest risk for developing cervical cancer, such as HIV infected women.
This study was limited by small size. Despite this, the study population is at high risk for cervical cancer and is underrepresented in the literature. Another limitation was the fact that participants were already part of a study of HPV and were given information about HPV in the consent process, suggesting that they may have over performed on the measure compared to the general female adolescent population.

Conclusion

Our study highlights the need for more education about cervical cancer prevention through both screening and vaccination, especially among high-risk adolescent women.

Acknowledgments

This work is supported by the National Institute of Allergy and Infectious Disease at the National Institutes of Health (5 K23AI07759-03, PI: David Adler)

Appendix A:

Prior Knowledge (True/False/Not sure)
Prior to enrollment in this study, I had heard of human papillomavirus (HPV)
Prior to enrollment in this study, I had heard of cervical cancer
I know someone who has been diagnosed with cervical cancer
HPV Knowledge (True/False/Not sure)
HPV is very rare (false)
HPV always has signs and symptoms (false)
HPV can cause cervical cancer (true)
HPV can be passed on by genital skin-to-skin contact (true)
There are many types of HPV (true)
HPV can cause HIV/AIDS (false)
HPV can be passed on during sexual intercourse (true)
HPV can cause genital warts (true)
Men cannot get HPV (false)
Using condoms reduces the risk of getting HPV (true)
HPV can be cured by antibiotics (false)
Having many sexual partners increases the risk of getting HPV (true)
HPV usually doesn’t need any treatment (true)
Most sexually active people will get HPV at some point in their lives (true)
A person could have HPV without knowing it (true)
Having sex at an early age increases the risk of getting HPV (true)
HPV testing
An HPV test can tell how long you have had an HPV infection (false)
If a woman tests positive for HPV she will definitely get cervical cancer (false)
An HPV test can be done at the same time as a Pap smear test (true)
HPV testing is used to indicate if the HPV vaccine is needed (false)
When you have an HPV test, you get the results the same day (false)
If an HPV test shows that a woman does not have HPV her risk of cervical cancer is low (true)
HPV vaccination
HPV vaccines require three doses (true)
The HPV vaccines offer protection against all sexually transmitted infections (false)
The HPV vaccines are most effective if given to people who have never had sex (true)
Someone who has had HPV vaccine cannot develop cervical cancer (false)
The HPV vaccines offer protection against most cervical cancers (true)
One of the HPV vaccines offers protection against genital warts (true)
Girls who have had the HPV vaccine do not need a Pap smear test when they are older (false)
Pap smear Knowledge (True/False/Not sure)
Pap smear testing is conducted to test for sexually transmitted infections (false)
Pap smear testing is conducted to test for cervical cancer (true)
Pap smear testing is conducted to test for pregnancy (false)
Cervical cancer can be prevented if detected early by routine Pap smears (true)
Cervical cancer can be cured if detected early (true)
Vaccine Acceptance
I would be willing to get a vaccine that prevents cervical cancer if free or low cost

References

  1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, et al. (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.Int J Cancer 136: E359-386.

  2. Stein L, Urban MI, O'Connell D, Yu XQ, Beral V, et al. (2008) The spectrum of human immunodeficiency virus-associated cancers in a South African black population: results from a case-control study, 1995-2004. Int J Cancer 122:2260-2265.

  3. Sun XW, Kuhn L, Ellerbrock TV, Chiasson MA, Bush TJ, et al. (1997) Human papillomavirus infection in women infected with the human immunodeficiency virus.N Engl J Med 337: 1343-1349.

  4. Palefsky JM, Minkoff H, Kalish LA, Levine A, Sacks HS, et al. (1999) Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women.J Natl Cancer Inst 91: 226-236.

  5. Perlman S, Wamai RG2, Bain PA3, Welty T4, Welty E4, et al. (2014) Knowledge and awareness of HPV vaccine and acceptability to vaccinate in sub-Saharan Africa: a systematic review.PLoS One 9: e90912.

  6. Waller J, Ostini R, Marlow LA, McCaffery K, Zimet G (2013) Validation of a measure of knowledge about human papillomavirus (HPV) using item response theory and classical test theory.Prev Med 56: 35-40.

  7. Marlow LA, Zimet GD, McCaffery KJ, Ostini R, Waller J (2013) Knowledge of human papillomavirus (HPV) and HPV vaccination: an international comparison.Vaccine 31: 763-769.

  8. Francis SA, Battle-Fisher M, Liverpool J, Hipple L, Mosavel M, et al. (2011) A qualitative analysis of South African women's knowledge, attitudes, and beliefs about HPV and cervical cancer prevention, vaccine awareness and acceptance, and maternal-child communication about sexual health.Vaccine 29: 8760-8765.

  9. Harries J, Moodley J, Barone MA, Mall S, Sinanovic E (2009) Preparing for HPV vaccination in South Africa: key challenges and opinions.Vaccine 27: 38-44.

  10. Francis SA, Nelson J, Liverpool J, Soogun S, Mofammere N, et al. (2010) Examining attitudes and knowledge about HPV and cervical cancer risk among female clinic attendees in Johannesburg, South Africa.Vaccine 28: 8026-8032.

  11. Hoque ME (2013) Awareness of cervical cancer, Papanicolau's smear and its utilization among female, final year undergraduates in Durban, South Africa.J Cancer Res Ther 9: 25-28.

  12. National Department of Health, South Africa (2010) Clinical Guidelines for the management of HIV & AIDS in adults and adolescents, National Department of Health South Africa 2010.

  13. Francis SA, Leser KA, Esmont EE, Griffith FM (2013) An analysis of key stakeholders' attitudes and beliefs about barriers and facilitating factors in the development of a cervical cancer prevention program in South Africa.Afr J Reprod Health 17: 158-168.

  14. Batra P, Kuhn L, Denny L (2010) Utilisation and outcomes of cervical cancer prevention services among HIV-infected women in Cape Town.S Afr Med J 100: 39-44.

  15. Fonn S, Bloch B, Mabina M, Carpenter S, Cronje H, et al. (2002) Prevalence of pre-cancerous lesions and cervical cancer in South Africa--a multicentre study.S Afr Med J 92: 148-156.

  16. Moodley I, Tathiah N, Mubaiwa V, Denny L (2013) High uptake of Gardasil vaccine among 9 - 12-year-old schoolgirls participating in an HPV vaccination demonstration project in KwaZulu-Natal, South Africa.S Afr Med J 103: 318-321.

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