Journal of Otology & RhinologyISSN: 2324-8785

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Case Report, J Otol Rhinol Vol: 3 Issue: 6

Mucosal Malignant Melanoma of Inferior Concha and Nasal Septum: A Case Report with Mutation Analysis

Ismail Yilmaz1, Evren Erkul2*, Gizem Narli1, Onuralp Kurt2, Zafer Kucukodaci1, Murat Salihoglu2, Ufuk Berber1 and Dilaver Demirel1
1Department of Pathology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey
2Department of Otorhinolaryngology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey
*Corresponding author : Dr. Evren Erkul
Department of Otorhinolaryngology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey
E-mail: [email protected]
Received: August 11, 2014 Accepted: October 21, 2014 Published: December 05, 2014
Citation: Yilmaz I, Erkul E, Narli G, Kurt O, Kucukodaci Z (2014) Mucosal Malignant Melanoma of Inferior Concha and Nasal Septum: A Case Report with Mutation Analysis. J Otol Rhinol 3:6. doi:10.4172/2324-8785.1000199

Abstract

Mucosal Malignant Melanoma of Inferior Concha and Nasal Septum: A Case Report with Mutation Analysis

Nasal and paranasal Mucosal Malign Melanoma’s occurs 0.5% of all Malign Melanomas. Sinonasal Mucosal Malign Melanoma often arises from lateral nasal wall and septum. We present molecular features (BRAF, NRAS, c-KIT and PDGFRA mutations) of a sixty-three-year-old male patient with primary sinonasal mucosal malignant melanoma with rarely localized synchronously in inferior concha and nasal septum. The patient underwent melanoma resection via endoscopic approach with negative surgical margins, right functional neck dissection and 6000 Gy radiotherapy after surgery. There was no tumor recurrence and metastasis at the ten month follow-up of the patient. Pathological studies revealed no mutations in the KIT gene (exons 9, 11, 13, 17 and 18), NRAS gene (exons 2 and 3), BRAF gene (exon 15) and the PDGFRA gene (exons 12 and 18) in this tumor. Our case is also unique with its concurrent localization in the nasal septum and inferior turbinate and with no mutations in BRAF, NRAS, c-KIT and PDGFRA genes. Primary sinonasal mucosal malignant melanomas are biologically different from cutaneous malignant melanomas and molecular features of these tumors need more investigation.

Keywords: Melanoma; Sinonasal; Mutation; Turbinate; Nasal

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