Endocrinology & Diabetes ResearchISSN: 2470-7570

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Editorial, J Metabonomics Metabolites Vol: 1 Issue: 1

New Insights into the Role of ENPP1 in Insulin Resistance

Wentong Pan, Manisha Chandalia and Nicola Abate*
Department of Medicine, Division of Endocrinology, Stark Diabetes Center, Institute for Translational Science (ITS), The University of Texas Medical Branch at Galveston, Texas, USA
Corresponding author : Nicola Abate, M.D
Department of Medicine, Division of Endocrinology, Stark Diabetes Center, Institute for Translational Science (ITS), The University of Texas Medical Branch at Galveston, Texas, USA
Tel: 409-772-6314; Fax: 409-772-8709
E-mail: [email protected]
Received: October 10, 2012 Accepted: October 12, 2012 Published: October 15, 2012
Citation: Pan W, Chandalia M, Abate N (2012) New Insights into the Role of ENPP1 in Insulin Resistance. J Metabonomics Metabolites 1:1. doi:10.4172/2325-9736.1000e103

Abstract

New Insights into the Role of ENPP1 in Insulin Resistance

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a transmembrane glycoprotein highly expressed in adipocytes and also found in other tissues involved in glucose and lipid metabolism, including liver, skeletal muscle and beta cell of the pancreas. Early studies demonstrated that ENPP1 interacts with the insulin receptor at the level of the alpha subunit. This interaction results in decreased insulin-mediated activation of the tyrosine phosphorylation in the beta-subunit of the insulin receptor, and downstream insulin signaling activation.

Keywords: ENPP1; ENPP1 K121Q; Obesity; Insulin Resistance

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