Journal of Womens Health, Issues and CareISSN: 2325-9795

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, J Womens Health Issues Care Vol: 5 Issue: 5

Acetowhite Test for Detection of Papilloma Virus Infection in Men Sexual Partner of Women Diagnosed of High Grade Cervical Lesions

Elena López-Diez1*, Sonia Pérez2, Amparo Iñarrea3, Angel dela Orden3, Máximo Castro1, J Carlos Diz4, Sheila Almuster1, Moises Rodríguez1, Ruben Montero1, Miguel Perez Schoch1 and Antonio Ojea1
1Department of Urology, University Hospital of Vigo, Spain
2Department of Microbiology, University Hospital of Vigo, Spain
3Department of Obstetrics and Gynecology, University Hospital of Vigo, Spain
4Department of Anesthesia, University Hospital of Vigo, Spain
Corresponding author : Elena López-Diez
Department of Urology, University Hospital of Vigo, Alvaro Cunqueiro s/n 36200 EOXI de Vigo Apartado oficial, Spain
Tel: 0034986811111 Ext 514639
Received: April 25, 2016 Accepted: June 15, 2016 Published: June 20, 2016
Citation: López-Diez E, Pérez S, Iñarrea A, Orden A, Castro M, et al. (2016) Acetowhite Test for Detection of Papilloma Virus Infection in Men Sexual Partner of Women Diagnosed of High Grade Cervical Lesions. J Womens Health, Issues Care 5:5. doi:10.4172/2325-9795.1000244


Background: Traditionally, men asked urologist for treatment of genital warts caused by low risk Papilloma virus (LR-HPV) but, recently, asymptomatic men also want to know if they are infected by high risk HPV (HR-HPV) and the benefits of HPV vaccine. The aims of this cross-sectional study were: (1) to evaluate acetowhite test usefulness for detection of asymptomatic and subclinical HRHPV infection in a high risk population of men and (2) to assess risk factors of HR-HPV infection in this population.
Methods: Healthy men (n=137) sexual partners of women with preneoplastic cervical lesions were recruited. Acetowhite test was performed (5% acetic acid solution, colposcopic examination under 4-fold and 7-fold magnification). Genital samples were obtained for HR-HPV DNA detection from different penile areas. (Linear Array HPV Genotyping Test, Roche Diagnostics, Mannheim, Germany). SPSS 19.0 (IBM, Chicago, USA) was used for statistical analysis.
Results: HR-HPV prevalence was 68/137 (49.6%). AW procedure was positive in 36/137 (26.3%) patients. Genital warts were present in 18/137 (13.1%) patients. Acetowhite test showed 25% sensitivity (95% CI: 13.9-36), 72.4% specificity (95% CI: 61.2-83.7), 47.2% predictive positive value (95% CI: 29.5-64.9) and 49.5% negative predictive value (95% CI: 39.2- 59.7) for the identification of HR-HPV infection. Subclinical lesions were detected in 16/68 (23.5%) infected males. Genital warts (p=0.010) were associated with an increased risk for HRHPV infection in men.
Conclusion: In our experience, acetowhite procedure sensitivity was low for HR-HPV detection in asymptomatic/subclinical genital infection and it was not specific indicator of HR-HPV infection. Genital warts detection was associated with HR-HPV infection in men.

Keywords: Human papilloma virus; DNA test; Male; Prevention; Cervical intraepithelial neoplasia; Mass Screening; Genital warts; Diagnosis

international publisher, scitechnol, subscription journals, subscription, international, publisher, science

Track Your Manuscript

Awards Nomination

Media Partners


open access