Short Communication, J Chem Appl Chem Eng Vol: 5 Issue: 5
Alanine Enhances Aminoglycosides-Induced ROS Production by Metabolic Regulation
Metabolite-enabled killing of antibiotic-resistant pathogens by antibiotics is an attractive strategy to manage antibiotic resistance. Our previous study demonstrated that alanine or/and glucose increased the killing efficacy of kanamycin on antibiotic-resistant bacteria, whose action is through up-regulating TCA cycle, increasing proton motive force and enhancing antibiotic uptake. Despite the fact that alanine altered several metabolic pathways, other mechanisms could be potentially involved in alanine-mediated kanamycin killing of bacteria which remains to be explored. In the present study, we adopted proteomic approach to analyze the proteome changes induced by exogenous alanine.
Keywords: Chemical Engineering
School of Life Sciences, Sun Yat-sen University, China