Journal of Proteomics & EnzymologyISSN: 2470-1289

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Review Article, J Proteomics Enzymol Vol: 6 Issue: 1

An Overview of Proteomics Techniques and its Application as a Tool in Biomarker and Drug Discovery

Roopesh Krishnankutty1, Ajaz A Bhat1, Asfar S Azmi2, Serhiy Souchelnytskyi3, Shahab Uddin1, Abdul B Abou-Samra1 and Ramzi M Mohammad1*
1Academic Health System, Translational Research Institute, Hamad Medical Corporation, Doha, State of Qatar
2Wayne State University School of Medicine, Detroit, Michigan, USA
3College of Medicine, Qatar University, Doha, State of Qatar
Corresponding author : Ramzi M. Mohammad, PhD
Professor, Director, Translational Research Institute, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar
Tel: (974)-443-90497
Fax: (974)-443-98792
E-mail: [email protected]
Received: October 04, 2016 Accepted: December 16, 2016 Published: January 19, 2017
Citation: Krishnankutty R, Bhat AA, Azmi AS, Souchelnytskyi S, Uddin S, et al. (2017) An Overview of Proteomics Techniques and its Application as a Tool in Biomarker and Drug Discovery. J Proteomics Enzymol 6:1. doi: 10.4172/2470-1289.1000129

Abstract

Introduction: Proteomics technology is extensively used to identify the underlying molecular mechanisms of various diseases. Emergent technologies in proteomics have been used in the biomarker and drug discovery process. Proper use of this technology can enable the understanding of mechanism of drug action; efficacy and toxicity, there by facilitating effective translation of the drug from bench to bedside.

Areas covered: The major techniques used in proteomics technology with an application in drug discovery process are discussed. An overview on different kinds of proteomic approaches and their application in various fields of biomarker discovery as well as drug development process has also been presented.

Conclusions: Proteomics technology serves as a promising approach by providing unbiased information about protein-protein interactions, post-translational modifications and regulatory mechanisms. Owing to the complexity of the proteomes the technology needs to be complemented with other omics techniques which could revolutionize drug development process. Advanced instrumentation with improved sensitivity, selectivity coupled with efficient proteomics work flows can facilitate comprehensive characterization of various proteomes for potential drug targets

Keywords: Biomarkers; Drug discovery; Mass spectrometry; Proteomics; Stable isotope labeling

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