Review Article, J Proteomics Enzymol Vol: 6 Issue: 1
An Overview of Proteomics Techniques and its Application as a Tool in Biomarker and Drug Discovery
|Roopesh Krishnankutty1, Ajaz A Bhat1, Asfar S Azmi2, Serhiy Souchelnytskyi3, Shahab Uddin1, Abdul B Abou-Samra1 and Ramzi M Mohammad1*|
|1Academic Health System, Translational Research Institute, Hamad Medical Corporation, Doha, State of Qatar|
|2Wayne State University School of Medicine, Detroit, Michigan, USA|
|3College of Medicine, Qatar University, Doha, State of Qatar|
|Corresponding author : Ramzi M. Mohammad, PhD
Professor, Director, Translational Research Institute, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar
E-mail: [email protected]
|Received: October 04, 2016 Accepted: December 16, 2016 Published: January 19, 2017|
|Citation: Krishnankutty R, Bhat AA, Azmi AS, Souchelnytskyi S, Uddin S, et al. (2017) An Overview of Proteomics Techniques and its Application as a Tool in Biomarker and Drug Discovery. J Proteomics Enzymol 6:1. doi: 10.4172/2470-1289.1000129|
Introduction: Proteomics technology is extensively used to identify the underlying molecular mechanisms of various diseases. Emergent technologies in proteomics have been used in the biomarker and drug discovery process. Proper use of this technology can enable the understanding of mechanism of drug action; efficacy and toxicity, there by facilitating effective translation of the drug from bench to bedside.
Areas covered: The major techniques used in proteomics technology with an application in drug discovery process are discussed. An overview on different kinds of proteomic approaches and their application in various fields of biomarker discovery as well as drug development process has also been presented.
Conclusions: Proteomics technology serves as a promising approach by providing unbiased information about protein-protein interactions, post-translational modifications and regulatory mechanisms. Owing to the complexity of the proteomes the technology needs to be complemented with other omics techniques which could revolutionize drug development process. Advanced instrumentation with improved sensitivity, selectivity coupled with efficient proteomics work flows can facilitate comprehensive characterization of various proteomes for potential drug targets