Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533

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Research Article, J Appl Bioinforma Comput Biol Vol: 5 Issue: 1

Anticarcinogenic Effects of Selected Alkaloids Identified from Cyperus Rotundus: An In Silico Perspective

Lydia J1* and Sudarsanam D2
1Department of Microbiology, Maharani’s Science College, Bangalore, India
2Department of Advanced Zoology, Biotechnology and Bioinformatics, Loyola College, Chennai, India
Corresponding author : Lydia J
Department of Microbiology, Research Associate: DBT-BIF, Maharani’s Science College, Bangalore, India
Tel: +91 80 2334 9311
E-mail: [email protected]
Received: February 02, 2016 Accepted: February 26, 2016 Published: February 29, 2016
Citation: Lydia J, Sudarsanam D (2016) Anticarcinogenic Effects of Selected Alkaloids Identified from Cyperus Rotundus: An In Silico Perspective. J Appl Bioinform Comput Biol 5:1. doi:10.4172/2329-9533.1000122

Abstract

Anticarcinogenic Effects of Selected Alkaloids Identified from Cyperus Rotundus: An In Silico Perspective

Cyperus rotundus Linn, commonly referred to as nut grass or purple nut sedge, is a perennial grass distributed widely in the warmer parts of the world. Various parts of the plant are being used as traditional remedies for diverse aliments. Five alkaloids identified from the ethanolic extract were modelled and docked with the emerging anticancer drug target, DNA polymerase β, which fill gaps during the repair of damaged DNA. The ADME properties of the alkaloids were also analysed and compared with that of Cytarabine. Two potential inhibitors of DNA polymerase β were identified, with ADME properties similar to that of cytarabine. It is therefore proposed that this compound, if isolated and purified, could be used for further in vivo or clinical studies. Three other alkaloids of which two were novel, presented exceptional ADME properties, but yielded lesser docking scores, suggesting that, a combination of the plants’ alkaloids would also be beneficial for anticancer therapy.

Keywords: Cyperus rotundus Linn; Alkaloids; Anticancer; DNA poly beta cytarabine

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