International Journal of Mental Health & PsychiatryISSN: 2471-4372

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Short Article, Int J Ment Health Psychiatry Vol: 5 Issue: 1

Bupropion with Linezolid: A Review

Divya Periasamy and Sachidanand Peteru*

Jamaica Hospital Medical Center, NY, USA

*Corresponding Author : Selvan T
MD, Jamaica Hospital Medical Center, 8900 Van Wyck Expy, Richmond Hill, NY 11418, USA,
Tel: 718-206-7135
E-mail: [email protected]

Received: December 26, 2018 Accepted: February 13, 2019 Published: February 19, 2019

Citation: Periasamy D, Peteru S (2019) Bupropion with Linezolid: A Review. Int J Ment Health Psychiatry 5:1. doi: 10.4172/2229-4473.1000225


Introduction: Linezolid (Zyvox) is an antibiotic, which belongs to the class of oxazolidinone. FDA approved it in 1998 to treat gram-positive drug-resistant enterococcus, staphylococcus, and pneumococcus infections in adults (MRSA and VRE). Bupropion (Welbutrin) is a medication primarily used as an antidepressant and smoking cessation aid. FDA first approved it in 1985. Both these medications are well known for causing serotonin syndrome when combined with serotonergic agents or administered along with tyramine-rich foods. Case: A 50-year old male patient was admitted to the hospital with right leg cellulitis and was treated with linezolid. The patient also had a history of depression and anxiety and was stable on bupropion for the past two years. Our C and L team was consulted for medication reconciliation and possible drug-drug interaction. On an extensive literature search, we came across just one case of hypertensive crisis when treated with linezolid and bupropion simultaneously. Hypertensive crisis from other confounding factors is unknown. We recommended continuing the prescribed bupropion on the patient along with his linezolid medication after explaining the risks and benefits. The patient completed his treatment and there were no symptoms suggestive of serotonin syndrome or hypertensive crisis. Conclusion: Bupropion was continued in a patient who was simultaneously treated with linezolid and pt completed the treatment without any symptoms of serotonin syndrome or hypertensive crisis. However, clinicians should be vigilant about drug-drug interactions and should make decisions on a case by case basis.

Keywords: Linezolid; Bupropion; MAO inhibitor; SSRI; SNRI; DNRI; Serotonin syndrome; Hypertensive crisis; FAERS; Neuroleptic malignant syndrome

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