Case Report, Arch Transplant Vol: 4 Issue: 2
Chronic Antibody Mediated Rejection, a Continuous and Complex Lesion
*Corresponding Author : Barreto S
Department of Nephrology, Hospital Garcia de Orta, Av. Torrado da Silva, 2805-267, Almada, Portugal
E-mail: [email protected]
Received: June 02, 2020 Accepted: June 23, 2020 Published: June 30, 2020
Citation: Barreto S, Silva N, Lamas N, Santos S, Malheiro J, Almeida M, Pedroso S, Martins MLS, Dias L, Henriques AC, Vizcaíno JR and Cabrita A (2020) Chronic Antibody Mediated Rejection, a Continuous and Complex Lesion. Arch Transplant 4:2. doi: 10.37532/at.2020.4(2).113
Introduction: With the advent of more potent immunosuppression, early outcomes after kidney transplantation have been excellent. However, the long-term survival of renal allograft remains a difficult and unanswered question as most of the renal transplants undergo failure within a decade. Case Report: A 43-year-old male with end-stage renal disease of undetermined aetiology was submitted to kidney transplantation from an ABO incompatible donor. During the first 12 months of follow-up, this patient was submitted to 6 biopsies in the context of worsening renal function. The first biopsy was Conclusion:The presence of pathogenic antibodies against non-HLA molecules should always be considered, particularly in the absence of detectable DSA with histological evidence of humoral response.