Archives of Transplantation.

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Case Report,  Arch Transplant Vol: 4 Issue: 2

Chronic Antibody Mediated Rejection, a Continuous and Complex Lesion

Barreto S1*, Silva N2, Lamas N3, Santos S4, Malheiro J4, Almeida M4, Pedroso S4, Martins MLS4, Dias L4, Henriques AC4, Vizcaíno JR3, Cabrita A4

1Department of Nephrology, Hospital Garcia de Orta, Almada, Portugal

2Department of Nephrology, Centro Hospitalar de Trás-Os-Montes e Alto Douro, Vila Real, Portugal

3Depart ment of Pathology, Centro Hospitalar Universitário do Porto, Porto, Portugal

4Renal Transplantation Unit, Centro Hospitalar Universitário do Porto, Porto, Portugal

*Corresponding Author : Barreto S
Department of Nephrology, Hospital Garcia de Orta, Av. Torrado da Silva, 2805-267, Almada, Portugal
Tel:
+351968855476
E-mail: [email protected]

Received: June 02, 2020 Accepted: June 23, 2020 Published: June 30, 2020

Citation: Barreto S, Silva N, Lamas N, Santos S, Malheiro J, Almeida M, Pedroso S, Martins MLS, Dias L, Henriques AC, Vizcaíno JR and Cabrita A (2020) Chronic Antibody Mediated Rejection, a Continuous and Complex Lesion. Arch Transplant 4:2. doi: 10.37532/at.2020.4(2).113

Abstract

Introduction: With the advent of more potent immunosuppression, early outcomes after kidney transplantation have been excellent. However, the long-term survival of renal allograft remains a difficult and unanswered question as most of the renal transplants undergo failure within a decade. Case Report: A 43-year-old male with end-stage renal disease of undetermined aetiology was submitted to kidney transplantation from an ABO incompatible donor. During the first 12 months of follow-up, this patient was submitted to 6 biopsies in the context of worsening renal function. The first biopsy was Conclusion:The presence of pathogenic antibodies against non-HLA molecules should always be considered, particularly in the absence of detectable DSA with histological evidence of humoral response.

Keywords: Chronic Antibody Mediated Rejection; ABO incompatibility; Kidney Transplantation; Non-HLA antibodies

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