Editorial, J Clin Genom Vol: 7 Issue: 1

Clinical Genomics in Precision Medicine

Ritu Sharma^*

Department of Genetics, All India Institute of Medical Sciences (AIIMS), New Delhi, India

*Corresponding Author:

Ritu Sharma
Department of Genetics, All India Institute of Medical Sciences (AIIMS), New Delhi, India
E-mail: ritu.sharma@aiims.edu

Received: 01-March-2025, Manuscript No. jcg-25-169327; Editor assigned: 4-March-2025, Pre-QC No. jcg-25-169327 (PQ); Reviewed: 20-March-2025, QC No jcg-25-169327; Revised: 26-March-2025, Manuscript No. jcg-25-169327 (R); Published: 30-March-2025, DOI: 10.4172/jcg.1000141

Citation: Ritu S (2025) Clinical Genomics in Precision Medicine. J Clin Genom 7:141

Introduction

Clinical genomics integrates genomic information into patient care, enabling precision medicine strategies. Advances in sequencing technologies and bioinformatics have allowed physicians to tailor treatments to an individual’s genetic profile. These developments significantly improve diagnosis, risk assessment, and therapy customization.

Genomic Profiling for Disease Prediction

Through genome-wide association studies (GWAS), researchers can identify susceptibility variants associated with diseases such as Type 2 diabetes, cardiovascular disorders, and asthma [1]. Polygenic risk scores derived from these studies can guide early interventions and preventive care [2]. In India, initiatives like GenomeIndia are enhancing understanding of disease-specific genetic markers in diverse populations [3].

Applications in Oncology

Genomics has transformed oncology through tumor profiling and identification of driver mutations such as EGFR, ALK, and KRAS [4]. Targeted therapies are improving survival in cancers with defined genomic alterations. Moreover, liquid biopsies for detecting circulating tumor DNA (ctDNA) provide non-invasive methods for monitoring treatment response and relapse [5].

References

1. Manolio TA (2009) Nature.
2. Torkamani A (2018) Nat Rev Genet.
3. (2022) GenomeIndia Consortium.
4. Garraway LA (2013) Cell.
5. Wan JCM (2017) Nat Rev Cancer.