Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Research Article, J Pharm Drug Deliv Res Vol: 7 Issue: 2

Comparative Studies of Different Brands of Metformin Hydrochloride Tablets in Local Market of Rawalpindi, Pakistan

Wajeeha Khalid1, Muhsin Jamal2*, Tahir Aqeel Malik1 and Shoaib Sarwar1

1Department of Pharmacy, University of Lahore, Islamabad Campus, Pakistan

2Department of Microbiology, Abdul Wali Khan University, Garden Campus, Mardan, Pakistan

*Corresponding Author : Dr. Muhsin Jamal
Department of Microbiology, Abdul Wali Khan University, Garden Campus, Mardan 23000, Pakistan, Tel: +92-346-9398028; E-mail: [email protected]

Received: August 18, 2018 Accepted: February 04, 2019 Published: February 13, 2019

Citation: Khalid W, Jamal M, Malik TA, Sarwar S (2018) Comparative Studies of Different Brands of Metformin Hydrochloride Tablets in Local Market of Rawalpindi, Pakistan. J Pharm Drug Deliv Res 7:2. doi: 10.4172/2325-9604.1000185

Abstract

Metformin hydrochloride is an anti-diabetic medicine that is used to improve blood sugar control in people with type II diabetes. There are several generics of metformin hydrochloride tablets available within the drug delivery system. Availability of numerous brands of metformin hydrochloride tablets in drug market today places health practitioners in a puzzle of generic substitution. Counterfeit, substandard and spurious “medicines” can increase risk of the drug resistance, cause economic loss for patients, health systems and pharmaceutical industries that can lead to morbidity and mortality rates. The aim of study was to assess and analyze the quality and standard of available brands of metformin hydrochloride (HCl) and to relate the results with United States Pharmacopeia (USP) standards. Five different brands of metformin-HCl tablets including both local and multinational brands that are commercially available in the market of Rawalpindi, Pakistan were subjected to comparative analysis according to the USP. The overall quality of brands was analyzed by subjecting to different pharmacopoeias and nonpharmacopoeias tests. The obtained results indicated that all of the examined products were in accordance with the pharmacopoeias specifications but the physical appearance of sample B5 (Metadox) was not acceptable.

Keywords: Metformin hydrochloride; Counterfeit; Friability; Disintegration

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