Journal of Chemistry and Applied Chemical EngineeringISSN : 2576-3954

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Editorial,  J Chem Appl Chem Eng Vol: 5 Issue: 5

Exogenous glutamate plus antibiotics kills multidrugresistant bacteria through a novel pathway that controls the TCA cycle

Hailey Robert


The emergence and ongoing spread of multidrug-resistant bacteria puts humans and other species at risk of potentially lethal infections. Thus, novel antibiotics or alternative approaches are needed to kill the drug-resistant bacteria. Here, the mechanism by which multidrugresistant Edwardsiella tarda evades killing by the traditional antibiotic kanamycin is explored using a reprogramming metabolomicsbased approach. The results demonstrate that exogenous glutamate restores the ability of kanamycin to kill E. tarda in vitro and in vivo. It stimulates the P cycle containing the TCA cycle, which stimulates production of NDAH, increases proton-motive force and stimulates antibiotic uptake.

Keywords: Material Science

Dhaka University, Bangladesh

international publisher, scitechnol, subscription journals, subscription, international, publisher, science

Track Your Manuscript

Recommended Conferences