Endocrinology & Diabetes ResearchISSN: 2470-7570

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Research Article, Endocrinol Diabetes Res Vol: 3 Issue: 1

Fat Distribution Patterns and Hormone Levels among Lean and Overweight PCOS Patients

Sylvia Kirchengast1* and Johannes Huber2

1Department of Anthropology, University of Vienna, Austria

2University Clinic for Gynaecology and Obstetrics, University of Vienna Medical School, Austria

*Corresponding Author : Sylvia Kirchengast
University Professor, Department for Anthropology, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria
E-mail: sylvia.kirchengast@univie.ac.at

Received: December 02, 2016 Accepted: December 24, 2016 Published: January 16, 2017

Citation: Kirchengast S, Huber J (2017) Fat Distribution Patterns and Hormone Levels among Lean and Overweight PCOS Patients. Endocrinol Diabetes Res 3:1. doi: 10.4172/2470-7570.1000116


Objective: Association patterns between body composition, fat distribution and hormonal levels were examined in lean and obese women suffering from polycystic ovary syndrome (PCOS).

Methods: 10 lean and 10 overweight women aging between 18 and 30 years (x=24.7yrs Sd=3.3) suffering from polycystic ovary syndrome were enrolled in the present study. Weight status was classified according to the body mass index categories of the World Health Organization. Body composition was determined by DEXA measurements, fat distribution patterns were quantified by the fat distribution index. Serum levels of estradiol, LH, FSH, progesterone, testosterone, DHEA-S, androstendione, SHBG, TSH, thyroxin, and growth hormone were determined. Additional hormone stimulation tests were performed.

Results: Lean and overweight PCO patients differed highly significantly in all body composition parameters and in fat distribution. Overweight PCOS patients exhibited a significantly higher amount of body fat, especially in the upper body region. Furthermore among overweight PCOS patients a centralized or android fat patterning prevails. The majority of lean PCOS patients exhibited an android or intermediate fat distribution; however 30% of the lean women showed a gynoid fat patterning. Overweight PCOS Patients showed significantly higher androgen levels than their lean counterparts. Body fat correlated significantly positively with thyroxin levels, but significantly negatively with growth hormone levels and SHBG levels. Testosterone correlated only insignificantly positively with the amount of body fat and android fat patterning.

Conclusion: Among lean as well as overweight PCOS patients a centralized fat patterning prevails. Hormonal levels are significantly associated with body composition parameters.

Keywords: Polycystic ovary syndrome; Androgen levels; Fat patterning; Body composition; Obesity

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