Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Research Article, J Pharm Drug Deliv Res Vol: 5 Issue: 6

Free Surface Electrospinning of Microemulsions Containing Vitamin E

Jeffrey T. Miller, Alexis Goebel, Matthew Lee and Keith M. Forward*
Department of Chemical and Materials Engineering, California State Polytechnic University, Pomona
Corresponding author : Keith M. Forward
Department of Chemical and Materials Engineering, California Polytechnic State University at Pomona, 3801 Temple Ave, 17-2104 Pomona, CA, USA
Tel: +1-909-869-3621
Fax: +1-909-869-6920
E-mail: [email protected]
Received: September 26, 2016 Accepted: October 25, 2016 Published: October 28, 2016
Citation: Miller JT, Goebel A, Lee M, Forward KM (2016) Free Surface Electrospinning of Microemulsions Containing Vitamin E. J Pharm Drug Deliv Res 5:6. doi: 10.4172/2325-9604.1000157

Abstract

In research and development of pharmaceutical products, an estimated 90% of active pharmaceutical ingredients (APIs) are insoluble or partially soluble in water. Due to poor solubility, these APIs exhibit poor bioavailability in solid dosage forms. To improve the release rate of APIs, free surface electrospinning of a microemulsion was considered as a means of producing submicron size domains of API dispersed in an amorphous excipient. Microemulsions containing a poor solubility API, vitamin E, and an excipient, Polyvinylpyrrolidone, are electrospun to produce a highly porous material with a high surface area, which promotes rapid drug release. The materials were characterized by scanning electron microscopy and high performance liquid chromatography to determine the morphology of the fibers and the bioavailability of the final material. The final product contained significant amounts of Vitamin E encapsulated within the excipient, and release rates were significantly improved over commercial products. In addition to improving the bioavailability of APIs, this technique may be utilized to streamline the downstream processing of pharmaceuticals, resulting in lower operating cost and improved uniformity over current batch manufacturing techniques.

Keywords: Vitamin E; Free surface electrospinning; Bioavailability; Drug solubility; Active Pharmaceutical ingredient; Pharmaceutical technology

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