Research Article, J Appl Bioinforma Comput Biol Vol: 10 Issue: 3
IMMUNE DB: A Large Internet Framework for Collecting and Analysing Biological Immune Results
Venu Paritala*, Rajashekhar Reddy S, Sukesh K and Bhargavi Pasupuleti
Department of Biotechnology Vignan’s Foundation for Science, Technology & Research is a Deemed University in the Guntur District in Andhra Pradesh, India
*Corresponding Author: Venu Paritala
Department of Biotechnology Vignan’s Foundation for Science, Technology & Research is a Deemed University in the Guntur District in Andhra Pradesh, India-522213
Received: May 13, 2021 Accepted: June 15, 2021 Published: June 22, 2021
Citation: Paritala V, Rajashekhar Reddy S, Sukesh K, Pasupuleti B (2021) IMMUNE DB: A Large Internet Framework for Collecting and Analysing Biological Immune Results. J Appl Bioinforma Comput Biol 10:6.
ata discovery is becoming increasingly dependent on bioinformatics analytic techniques and access to curated data repositories related to immune responses and particular pathogens. With the exponential growth of biological evidence, a growing number of biological databases have been created to assist humanimmune system-related research. We present a list of humanimmune system- related biological datasets and provided a minireview by categorizing them into various data forms. This paper is largely aimed at computer scientists with only a rudimentary understanding of biology Databases are replacing science literature as a means of disseminating this knowledge to the public immune disease database (https://venuparitala.shinyapps.io/immune_db/) apprehend the data cramped in figures, text, tables of the scientific literature promise it freely available and easily searchable to the public. Immune DB will assist biological researchers to explore about immune system categorized innate, autoimmune, and adaptive immune systems, each category has multiple disorders, each disorder has its own control and gene catalogue in summation with targets and networks. It discusses how to enhance immunity and which foods and medicines women and children can take. We covered which age individuals are suffering more, then after the information is provided about covid19 effects, symptoms, control, genes take place and collection of literature. It reflects the number of people of a certain age who have immune deficiency, as well as the percentage of people who can avoid and tolerate it. , this index includes all facets of 14 auto immune disorders, 1 adaptive immune disease, and 6 innate immune diseases, this database, which is accessible, compact, and open-source, should be useful to all.
Keywords: Network; genes; Targets, Database; Covid19; Disease
The immune system keeps track of any germ (microbe) it has ever overcome so it can easily recognize and eliminate the microbe if it re-enters the body. as the field of bioinformatics has developed and developed into an unused department of science, unused subdisciplines have risen inside its immunoinformatic, the application of immunoinformatic to create a database and computational antibody plan [1-3]. The database is populated utilizing data captured or curated from peer-reviewed logical writing and from information submitted by analysts. The immune system is a complex network of cells and proteins that fights infection in the body. The immune system classified into different types Adaptive immune diseases, innative immune disease, immunodeficiencies, and autoimmune disorders may also caused by immune system abnormalities [4-8]. List of diseases included in this database:(I) Innative immune diseases:1.Chronic Granulomatous Phagocytic Disease,2. Primary Immune Deficiency,3. Complement Deficiencies,4. Hyper IgE Syndrome,5. Innate Immune Defects, 6. NEMO Deficiency Syndrome.(II)Autoimmune immune disorders: 1.Type 1 diabetes, 2. Rheumatoid arthritis, 3. Psoriasis/psoriatic arthritis, 4. Multiple sclerosis, 5. Systemic lupus erythematosus,6. Inflammatory bowel disease, 7. Addison’s disease, 8. Graves’ disease, 9. Sjogren’s syndrome,10. Hashimotos thyroiditis, 11. Myasthenia gravis, 12. Autoimmune vasculitis,13. Pernicious anemia, 14. Celiac disease.(III)Adaptive immune disorders:1.Rheumatic diseases.
Nearly 4% of the world’s population is affected by one of more than 80 different autoimmune diseases, the most common of which include type 1 diabetes, multiple sclerosis, rheumatoid arthritis, lupus, Crohn’s disease, psoriasis and sclerodermas. Overall, 78% of people affected by autoimmune disease are female many people suffering from immunodeficiency in one million (Primary Immunodeficiency Disorders in India—A Situational Review.) CVID is estimated to affect 1 in 25,000 to 1 in 50,000 people worldwide, although the prevalence can vary across different populations (https://medlineplus.gov/ genetics/condition/common-variable-immune-deficiency/s). The database contains the almost all literature related to immune disease, it consists of disease information about disease causing organism, disease type, how to control, genes and target of each disease and also found covid 19 data, genes, literature [9,10,11]. The purpose of database is to crating awareness among the people, reduce the amount of time you spend managing data. analyse data in a variety of ways. promote a disciplined approach to data management. turn disparate information into a valuable resource [12,13]. Genetic information or genetic test results can be used to prevent the onset of diseases, or to assure early detection and treatment, or to make reproductive decisions. This information can also be used for nonmedical purposes [14-16].
Target proteins are functional biomolecules that are addressed and controlled by biologically active compounds [17-19]. They are used in the processes of transduction, transformation and conjugation, target proteins controls the action and the kinetic behavior of drugs within the organism [20-22].
Materials and Methods
IMMUNE DB web application is developed with R software. The server is hosted in a cloud platform. For the development of the analytical pipeline, used various R packages [23-25]. The packages are shiny themes, shinydashboard, shiny, bootstrap, shinycustomloader, htmltools, htmlwidgets, DT, ggplot2, slideview, shinycssloaders, shiny Widgets, leaflet, network, igraph, googleform, ggnetwork, shinyanimat. It contains both the user interface and server [26,27].
Result and Discussion
Home: This tab panel contains the overall information about the database, which represents in textual and graphically.
Immune system: This item divided into three different categories innative immunity, autoimmune immunity and adaptive immunity, each category represents different types of diseases, each disease was explained with the information about disease and disease class. Filters are available to make job easy and user-friendly.
Immune Disease: Tab panel divided into three different categories, innative immunity, autoimmune immunity and adaptive immunity disease each category represents different types of diseases, each disease was explained with the information about disease symptoms and disease type. Filters are available to make job easy and user-friendly.
Control: The item was separated into three distinctive categories, to be specific natural insusceptibility, immune system resistance, and versatile resistance each category has a few disoredrs, each one clarifies the data malady control. Filters can be used to make the job simpler and more user- friendly.
Improve immunity: This tab panel segregate drugs into improve immunity, food to improve immunity and progeny colonize improve immunity. drugs to improve immunity subpanel consists of name of the drug and its uses, food to improve immunity subpanel consists name of the food, food category and vitamins, Filters can be used to make the job simpler and more user-friendly.
Genes: This genes tab panel represents all diseases when you select a disease it displays all possible gene names with gene symbol and frequency. On the left hand of the dashboard page click on the disease tab panel to explore about/gene information on another hand. it presents the top filters which easily search specify the gene name, it plots a graph between gene symbol and frequency which represents which disease is affecting more for eg: T code 30 times is more vital than others.
Targets: This targets tab panel represents all diseases when you select a disease its display’s all possible targets with organism type, targets, compound, accession id and taxonomic id.
Immune deficiency age: The tab panel contains the overall information about the age of the person, immune deficiency occur, percentage of causing immune deficiency and percentage of cure immune deficiency it represented in tables and graphically (Figure 1).
Covid19: This tab panel contains the information about corona virus, symptoms, prevention, genes and literature, it presents the data graphically.
Abstract find: This tab panel contains the literature of the all immune diseases, each article contain the PMCID, first author, title and published book and publishing year. Filters can be used to make the job simpler and more user-friendly .
Availability and Implementations
IMMUNE DB available at: https://venuparitala.shinyapps.io/ immune_db/
Supplementary information: supplementary data available in bioinformatics online
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