Endocrinology & Diabetes ResearchISSN: 2470-7570

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Case Report, Endocrinol Diabetes Res Vol: 3 Issue: 1

Licorice Edema

Taylor Hendrickson1, Hannah Oliver1 and Udaya M Kabadi1-3*

1Des Moines University Des Moines, Iowa, USA

2Veterans Affairs Medical Center Des Moines, Iowa, USA

3University of Iowa, Iowa City, Iowa, USA

Corresponding author : Udaya M Kabadi
Adjunct Professor of Medicine, Des Moines University, Des Moines, 17185, Berkshire Parkway Clive, Iowa, USA
Tel: 319-594-8575
E-mail: ukabadi@gmail.com

Received: July 27, 2016 Accepted: December 24, 2016 Published: January 09, 2017

Citation: Hendrickson T, Oliver H, Kabadi UM (2017) Licorice Edema. Endocrinol Diabetes Res 3:1. doi: 10.4172/2470-7570.1000115


Chronic ingestion of licorice is reported to induce hypertension and hypokalemic metabolic alkalosis with low aldosterone and is therefore labeled pseudohyperaldosteronism. Edema alone is rarely described. Herein, we report a subject who presented with generalized edema and prehypertension with failure to detect the causative disorder despite evaluation by several consultants. A detailed interogation revealed onset of edema following use of chewing Tobacco for over 6 months after cessation of cigarette smoking. Prehypertension was noted on physical examination. Laboratory testing documented renal sodium retention with subnormal plasma renin activity and aldosterone as well as elevated both plasma and urinary cortisol/cortisone ratios indicating inhibition of renal 11-OHSD 2 enzyme and the active ingredients in licorice used to flavour chewing tobacco is well established to inhibit renal 11-OHSD 2 enzyme resulting in edema and prehypertension characterized as pseudohyperaldosteronism. Finally, remission of edema and reversal to normal blood pressure on abstinence from chewing tobacco confirms role of licorice in induction of edema in this subject

Keywords: Licorice; Hyperaldosteronism; Pseudo-hyperaldosteronism; Glycyrrhetinic acid; 11 beta-hydroxysteroid dehydrogenase 2

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