Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533

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Research Article, J Appl Bioinforma Comput Biol Vol: 5 Issue: 1

Obesity-Related Genes and Oral Cancer: A Bioinformatics Approach and Systematic Review

Eliane Macedo Sobrinho Santos1,2, Hércules Otacílio Santos3,Sueli Nunes Fonseca1, Talita Antunes Guimarães1, Carlos Alberto de Carvalho Fraga1, Kimberly Marie Jones4, Alfredo Maurício Batista de Paula1, Sérgio Henrique Souza Santos5, André Luiz Sena Guimarães1 and Lucyana Conceiccedil;ão Farias1*
1Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil
2Instituto Federal do Norte de Minas Gerais - Campus Araçuaí, Minas Gerais, Brazil
3Instituto Federal do Norte de Minas Gerais - Campus Salinas, Minas Gerais, Brazil
4Dean of Research, Associação Educativa do Brasil (SOEBRAS) Plataforma Norte, Montes Claros, Minas Gerais, Brazil
5Department of Pharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Corresponding author : Lucyana Conceição Farias Lucyana Conceição Farias, Universidade Estadual de Montes Claros, Hospital Universitário Clemente de Faria, Laboratório de Pesquisa, 562 Cula Mangabeira Avenue, Santo Expedito, Montes Claros, MG, Brazil Tel: +55 38 32248327 E-mail: [email protected]
Received: March 10, 2016 Accepted: April 25, 2016 Published: April 31, 2016
Citation: Santos EMS, Santos HO, Fonseca SN, Guimarães TA, Fraga CAC, et al. (2016) Obesity-Related Genes and Oral Cancer: A Bioinformatics Approach and Systematic Review. J Appl Bioinform Comput Biol 5:1. doi:10.4172/2329-9533.1000124

Abstract

Obesity-Related Genes and Oral Cancer: A Bioinformatics Approach and Systematic Review

It is important to understand the biological processes linking obesity and cancer to identify new molecular targets for development of better therapeutic strategies. This study aims to synthesize knowledge regarding possible associations between obesity-related genes and oral cancer. We performed literature review about “oral cancer” and “obesity”. Gene databases and bioinformatics algorithms were used to in silico investigation of interactions networks between proteincoding genes, leader genes and molecular pathways that can possibly to link both pathological mechanisms. To this, GeneCards database, softwares STRING, Metaboanalyst and Cytoscape were employed. Genes were found to interact directly or indirectly with both obesity and oral cancer. Analyses of clustering revealed the TP53 gene as leader gene. Leptin was presented in group with the highest scores of relevance. Protein-protein interaction network linking obesity and oral cancer exhibits a power law behavior (correlation: 0.907; R2:0.851). Analysis of linear regression shows that genes related to obesity and oral cancer have higher diseaserelated connectivity than a global connectivity. Onthological analysis demonstrated different mechanisms associated to obesity and oral cancer, such as regulation of apoptosis and positive regulation of cellular process. We hypothesized that leptin is a molecule key in the link between obesity and oral cancer, by interactions with the p53 protein through CREBBP and EP300 proteins and HIF-1α, promoting angiogenesis. This study sought to organize relevant informations to further illuminate the role of genes that may be related to obesity and oral cancer. Angiogenesis genes can to be suggested as important factors to link both pathological processes..

Keywords: Leptin; Angiogenesis; Cell proliferation; Leader gene; Oral squamous cell carcinoma; Obesity

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