Research Article, J Pharm Drug Deliv Res Vol: 6 Issue: 2
Pretreatment with Microneedle Array to Improve the Nail Permeability
Kushwaha AS and Narasimha Murthy S*
The University of Mississippi, School of Pharmacy, University, MS, USA
Received: July 12, 2017 Accepted: August 05, 2017 Published: August 09, 2017
Citation: Kushwaha AS, Narasimha Murthy S (2017) Pretreatment with Microneedle Array to Improve the Nail Permeability. J Pharm Drug Deliv Res 6:2. doi: 10.4172/2325-9604.1000168
The objective was to investigate the feasibility of pretreatment with solid microneedles as an approach to improve the nail permeability to drugs. In vitro permeation studies were performed across the human nail plates which were pretreated with solid titanium microneedles (0.5 mm). Human nail plates without pretreatment were used as a control. Sodium fluorescein was used as a model dye. Microscopic studies were performed to visualize the distribution of sodium fluorescein in the nail plate. The amount of sodium fluorescein permeated in the receiver compartment after 7 days of studies was found to be ~123 fold more compared to control. The amount of sodium fluorescein retained in active and peripheral diffusion areas of nail plate was found to be ~4 fold and ~3 fold more relative to control. Overall, pre-treatment of the nail plate with metal microneedles is appeared to be feasible approach to deliver a significant amount of drugs into and across the nail plate.