Case Report, Int J Ment Health Psychiatry Vol: 3 Issue: 4
Progression of Autism in a Young Woman with CHARGE Syndrome: A Longitudinal Follow-up from Birth
Priscilla Hamiaux1,2, Jean Xavier3,4, Elisabeth Lasserre5, Didier Périsse3, Karine Baudelaire6, Vincent Guinchat3, David Cohen3, Laurence Vaivre-Douret1,2,7,8,9 and Véronique Abadie1,2*
1INSERM UMR 1178 and CESP, University of Paris-Sud Saclay, UVSQ and University of Paris Descartes, Sorbonne Paris City, France
2Faculty of Medicine, University of Paris Descartes, Sorbonne Paris City, France
3Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Assistance Publique - Hôpitaux de Paris, Groupe hospitalier Pitié- Salpêtrière, Paris, France
4ISIR, CNRS, UMR 7222, Université Pierre et Marie Curie, Paris, France
5Centre de resource Robert Laplane, Paris, France
6Institut Paul Sivadon, Paris France
7Department of child psychiatry, Necker University Hospital, AP-HP, Paris, France
8Institut Universitaire de France, Paris, France
9Department of Paediatrics, Necker University Hospital, AP-HP, Paris, France
*Corresponding Author : Véronique Abadie
K Service de pédiatrie générale, Hôpital Universitaire Necker 149 rue de Sèvres, 75015 Paris, France
Tel: 0033171196321
E-mail: veronique.abadie@aphp.fr
Received: August 11, 2017 Accepted: September 01, 2017 Published: September 06, 2017
Citation: Hamiaux P, Xavier J, Lasserre E, Périsse D, Baudelaire K, et al. (2017) Progression of Autism in a Young Woman with CHARGE Syndrome: A Longitudinal Follow-up from Birth. Int J Ment Health Psychiatry 3:4. doi: 10.4172/2471-4372.1000149
Abstract
CHARGE Syndrome (CS) is a rare genetic disease involving somatic malformations and multisensory impairments. The association of CS with autism spectrum disorders remains a controversial issue because it remains challenging to clinically assess symptoms of autism in young children with potential severe somatic conditions, deaf blindness and mental delay and the behavior troubles often encountered in individuals with CS can be considered the consequence of their multisensory deficits and medical history. We report the complex developmental trajectory of a 25-year-old girl with typical CS, with emotional disorders and problematic behaviors that led to a diagnosis of autism. Addressed by a multidimensional and integrative perspective, this situation reveals the coexistence of factors and impairments not causally connected but whose constant interactions during her development must be evaluated. In this way, clinicians can achieve a functional diagnosis enabling the elaboration of a tailored therapeutic proposal.
