Opinion Article, J Appl Bioinformat Computat Biol Vol: 10 Issue: 2
Navya Sree Nuthalapati*
Department of Pharmacy, QIS College of Pharmacy, Prakasam, AP, India
Received: February 04, 2021 Accepted: February 18, 2021 Published: February 25, 2021
Citation: Nuthalapti N(2021) SARS-CoV-2Genome 10(2).199.
Coronavirus sickness (COVID-19) is associate degree communicable disease caused by a completely unique severe acute metabolic process syndrome coronavirus two (SARS-CoV-2) that originally started in metropolis province in China and has currently affected >200 countries worldwide and declared a plague. The virus primarily affects the system inflicting flu-like sickness with symptoms like a cough, fever, and in additional severe cases, problem respiratory . As per the statistics out there, mortality is high in older cohort people (>60 years of age) different people and folks} with other morbid conditions. Additionally to acute metabolic process distress syndrome and metabolic process failure, COVID-19 is currently notable to manifest as general inflammation, resulting in infection, Acute viscus injury, and coronary failure and multi-organ pathology in patients at high risk
Keywords: SARS-CoV-2, Genome
The Origin and Genomic Structure of SARS-CoV-2
Firstly, the ordination sequence of SARS-CoV-2 was free in GenBank on January eleven, 2020 (accession no. MN908947.3). supported the sequence alignment and biological process tree analysis, SARS-CoV-2 is currently thought of because the newest member of the lineage B of genus Betacoronavirus (β-CoV) within the family of Coronaviridae of the order Nidovirales . The initial comparative genomic analysis illustrated that SARS-CoV-2 has nearly seventy nine and five hundredth sequence identity with SARS-CoV and also the Middle East metabolic process.
Genetic Diversity of SARS-CoV-2
Similar to the opposite polymer viruses, genetic diversity in SARS-CoV-2 is essential for its fitness, survival, and possibly its pathologic process. in a very study performed on the origin of SARS-CoV-2, it had been shown that random mutations and recombination area unit 2 main sources for genetic diversity during this virus. during this regard, 9 supposed recombinant patterns were known within the SARS-CoV-2 ordination, together with six essential recombination regions within the S sequence, and one in every of RdRp, nsp13, and ORF3a.
Phenotypic Options and Genomic Structures of SARS-CoV-2
The phenotypical options of CoVs area unit as follows. The microorganism particles area unit spherical, one hundred to 120 nm in diameter, with envelopes derived from the host cell wall. CoVs were named “coronaviruses” as a result of they're characterised by spike supermolecule projections on the surface of the microorganism particles (about 20 nm in length), and their form resembles a crown(corona) below microscopy.
Although solely a few 0.5 year has passed since a ordination sequence of SARS-CoV-2 was shared within the GISAID information, quite thirty,000 genomes area unit currently out there. mistreatment the ordination sequence knowledge with closely connected microorganism ordination knowledge, the genomic characteristics and evolution of SARS-CoV-2 were extensively studied. However, SARS-CoV-2 remains prevailing round the world and is inflicting several deaths. additional microorganism genomic and experimental medical specialty analyses area unit needed to characterize SARS-CoV-2.
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