Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533

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Research Article, J Appl Bioinform Comput Biol Vol: 4 Issue: 1

Semi-Automated Image Processing for Preclinical Bioluminescent Imaging

Nikolai V Slavine1* and Roderick W McColl2
1Department of Radiology, Division of Translational Research, UT Southwestern Medical Centre, Dallas, USA
2Department of Radiology, Division of Clinical Medical Physics, UT Southwestern Medical Centre, Dallas, USA
Corresponding author : Nikolai V Slavine
Department of Radiology, Division of Translational Research, UT Southwestern Medical Center, Dallas, USA
Tel: 214-648-9196;
E-mail: [email protected]
Received: December 16, 2014 Accepted: March 06, 2015 Published: March 13, 2015
Citation: Slavine NV, McColl RW (2015) Semi-automated Image Processing for Preclinical Bioluminescent Imaging. J Appl Bioinform Comput Biol 4:1. doi:10.4172/2329-9533.1000114

Abstract

Semi-automated Image Processing for Preclinical Bioluminescent Imaging

Small animal bioluminescence imaging (BLI) is used to observe noninvasively and in real time the presence or activation of specific biological process at the molecular level. With a multi-camera BLI device capable of tomographic studies, the 3D spatial distribution and temporal dynamics of luciferase expressing cells within the animal can be measured in great detail.

Keywords: Bioluminescent imaging; Tomography; CCD cameras; Light diffusion; 3D Iterative reconstruction; Lung cancer model

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