Journal of Pharmaceutics & Drug Delivery Research .ISSN: 2325-9604

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Case Report,  J Pharm Drug Deliv Res Vol: 9 Issue: 2

Synergistic Effect of Cefoperazone and Warfarin Leading to Fatal Coagulopathy in Patients on Warfarin Therapy After Valve Replacement Surgery. Series of Two Case Reports

Asad M1 , Liaqat A1* , and Shaukat F2

1Armed forces institute of cardiology, National institute of heart diseases. Rawalpindi Pakistan

2Riphah International University, Institute of Pharmaceutical Sciences, Islamabad Pakistan

*Corresponding Author : Liaqat A
Armed forces institute of cardiology, National institute of heart diseases. Rawalpindi Pakistan
E-mail:
[email protected]

Received date: June 2,2020; Accepted date: June 09,2020; Published date: June 23,2020

Citation: Asad M , Liaqat A, and Shaukat F (2020) Synergistic Effect of Cefoperazone and Warfarin Leading to Fatal Coagulopathy in Patients on Warfarin Therapy After Valve Replacement Surgery. Series of Two Case Reports. J Pharm Drug Deliv Res 9:2. doi: 10.37532/jpddr.2020.9(2).193

Abstract

Warfarin is one of the most commonly prescribed oral anticoagulant in hospital settings. It is deemed to have a large range of interactions with other drugs commonly used in clinical practice, including antibiotics, resulting in alteration in coagulation parameters as well as causing bleeding in some of these patients. We report two such cases of post valve replacement that developed exaggerated hypoprothombinemic response, which improved after replacement of cefoperazone with the other antibiotic. Although there is no direct evidence of warfarin-cefaperazone interaction, but based on these reports it is advisable that healthcare professionals should consider alternative antibiotic selection in patients on warfarin therapy, and consider close monitoring of coagulation profile for all those patients who receives concomitant warfarin and antibiotics, with appropriate adjustment of warfarin dosage.

Keywords: Warfarin; Valve replacement surgery; Major bleeding; Cefoperazone

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