Commentary, J Pharm Drug Deliv Res Vol: 12 Issue: 2
The Pharmaceutics Science and Technology of Drug Formulation and Delivery
Received date: 18 February, 2023, Manuscript No. JPDDR-23-96770;
Editor assigned date: 20 February, 2023, PreQC No. JPDDR-23-96770 (PQ);
Reviewed date: 06 March, 2023, QC No. JPDDR-23-96770;
Revised date: 13 March, 2023, Manuscript No. JPDDR-23-96770 (R);
Published date: 20 March, 2023, DOI: 10.4172/2325-9604.1000215
Citation: Chorilli M (2023) The Pharmaceutics Science and Technology of Drug Formulation and Delivery. J Pharm Drug Deliv Res 12:2.
Pharmaceutics is a branch of pharmacy that deals with the science and technology of designing, developing, and manufacturing drugs in the form of dosage forms for safe and effective delivery to patients. It encompasses various aspects of drug development, including drug discovery, drug delivery systems, and drug formulation.
The goal of pharmaceutics is to develop safe, effective, and stable dosage forms that can deliver the drug to the target site in the body at the appropriate rate and concentration. The dosage forms may include tablets, capsules, injections, inhalers, creams, ointments, and transdermal patches, among others.
Drug discovery is the initial phase of pharmaceutics that involves identifying potential drug candidates from natural or synthetic sources. Once a drug candidate is identified, it undergoes pre-clinical studies to assess its safety, efficacy, and pharmacokinetic properties. This information is used to develop a dosage form that can deliver the drug to the target site in the body.
Drug delivery systems are technologies used to transport drugs to the site of action in the body. These systems may include nanoparticles, liposomes, and other delivery systems that can improve the bioavailability and therapeutic efficacy of the drug. For example, liposomes can be used to deliver drugs to specific tissues or cells in the body, such as cancer cells.
Drug formulation is the process of developing a dosage form that can deliver the drug to the target site in the body. The formulation process involves selecting suitable excipients, such as binders, fillers, and disintegrates, to optimize drug stability, bioavailability, and efficacy. Excipients can also affect the physical properties of the dosage form, such as its appearance, texture, and taste.
The formulation process also involves selecting the appropriate manufacturing method to ensure consistency in drug quality and performance. This includes processes such as blending, granulation, compression, and coating, among others.
Pharmaceutics also involves the development of drug delivery systems that can improve patient compliance, such as sustainedrelease formulations, transdermal patches, and inhalers. Sustainedrelease formulations release the drug over an extended period, reducing the frequency of dosing and improving patient adherence. Transdermal patches deliver the drug through the skin, avoiding the need for oral administration. Inhalers are used to deliver drugs directly to the lungs for the treatment of respiratory diseases.
Pharmaceutics is an interdisciplinary field that combines chemistry, biology, engineering, and medicine to develop safe, effective, and stable drug dosage forms for delivery to patients. It plays an important role in drug development, ensuring that drugs are delivered to the target site in the body at the appropriate rate and concentration. The science and technology of pharmaceutics continue to evolve, with on-going research aimed at improving drug delivery and patient outcomes.