Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Review Article, J Clin Exp Oncol Vol: 5 Issue: 2

The Role of MicroRNAs in Cancer Progression

Seyedeh Elham Norollahi1, Majid Alipour1, Novin Nikbakhsh2, Hassan Taheri3, Mohammad Taghi Hamidian3, Sadegh Fattahi4, Seyed Reza Tabaripour1, Aghil Mollatabar Hassan1, Amir Hossein Esmaili1, Ali Akbar Samadani4*, Sara Hallajian5, Saed Alinejade Moalemi1, Amir Mahmoud Afshar6
1Department of Biology, Islamic Azad University of Babol, Babol, Iran
2Department of Surgery, Babol University of Medical Sciences, Babol, Iran
3Department of Gastroenterology, Babol university of Medical Sciences, Babol, Iran
4Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
5Department of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran (IAUPS)
6Department of Medicinary, Shahid Beheshti University of medical sciences, Tehran, Iran
Corresponding author : Ali Akbar Samadani
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
Tel: +98 11 32196476
E-mail: [email protected]
Received: December 28, 2015 Accepted: March 29, 2016 Published: April 04, 2016
Citation: Norollahi SE, Alipour M, Nikbakhsh N, Taheri H, Hamidian MT, et al. (2016) The Role of MicroRNAs in Cancer Progression. J Clin Exp Oncol 5:2. doi:10.4172/2324-9110.1000155

Abstract

MicroRNAs or miRNAs are none coding RNAs with eclectic biological functions and mechanism. They also have remarkable and pathological implications in many serious diseases. Correspondingly, given their role as post-transcriptional gene expression regulators, they are included in several important physiological processes such as: cell signaling, development and cell differentiation. Thus, miRNAs perform as modulators of gene expression programs in diverse diseases, especially in cancer development, where they accomplish through the expression of genes which are essential for carcinogenesis process. Relatively, the expression level of mature miRNAs is the conclusion of a well done mechanism of biogenesis, done by diverse enzymatic processes that assert their activities at transcriptional and post-transcriptional stages. In this review article we discuss and focus the molecular mechanism in conjunction with potential applications of microRNAs for the clinical and practical approaches in cancer development. Interestingly, we also cover the importance or to be affected by genetic and also epigenetic factors.

Keywords: MicroRNA; Therapy; Cancer; Epigenetic cancer

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