Journal of Otology & RhinologyISSN: 2324-8785

Reach Us +1 850 754 6199

Research Article, J Otol Rhinol S Vol: 0 Issue: 1

Peroxide Tone in Human Inferior Nasal Turbinate with Allergy

Masato Miwa1*, Noritsugu Ono1, Daisuke Sasaki1, Akihito Shiozawa1, Mayumi Miwa2 and Katsuhisa Ikeda1
1Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan
2Harimazaka Clinic, 4-20-2 Koishikawa, Tokyo, Japan
Corresponding author : Masato Miwa, MD
2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Tel: +81-3-5802-1094; Fax: +81-3-5689-0547
E-mail: [email protected]
Received: November 17, 2014 Accepted: January 16, 2015 Published: March 07, 2015
Citation: Miwa M, Ono N, Sasaki D, Shiozawa A, Miwa M, et al. (2015) Peroxide Tone in Human Inferior Nasal Turbinate with Allergy. J Otol Rhinol S1:1. doi:10.4172/2324-8785.S1-004

Abstract

Background: The nose is chronically exposed to oxidative stress, which can easily lead to reactive oxygen species (ROS)-mediated damage and lipid oxidative damage of the upper airway. ROS may also participate in various diseases, including those of the airway, although many details are not yet known.

ROS is generated by various enzymatic reactions and chemical processes. Superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) are representative scavengers. ROS are also generated through arachidonic acid cascades. One of the primary prostaglandins (PG), PGD2, is the major PG in most types of tissue, including the nose. We attempted to evaluate the peroxide tone by measuring these factors.

Methods: A total of 42 Japanese patients with and without nasal allergies were enrolled in this study. We determined the contents of lipid peroxide (LPO) and PGD2, as well as the activities of SOD, catalase, and GSH-Px of the anterior portion of the mucosa of the inferior turbinate, obtained by inferior turbinotomy.

Results: LPO and PGD2 contents increased significantly in the nasal allergy group. No statistically significant difference appeared in the activities of SOD, catalase, and GSH-Px were demonstrated in the nasal allergy group compared with the subjects without nasal allergy.

Conclusion: The imbalance of the peroxide tone in the nasal mucosa caused by stimulation of the cyclooxygenase pathway of the arachidonic acid cascade and ROS formation was demonstrated. Moreover, the increased number of ROS was not well metabolized in the nasal mucosa with allergy.

Keywords: Allergic rhinitis; Reactive oxygen species; Prostaglandin D2; Nasal mucosa; Superoxide dismutase; Catalase, Glutathione peroxidase; Lipid peroxide

Track Your Manuscript

Share This Page

Media Partners

Associations