Journal of Womens Health, Issues and Care ISSN: 2325-9795

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Review Article, J Womens Health Issues Care Vol: 2 Issue: 5

Pharmacogenetics of Apolipoprotein E on Donepezil and Fluoxetine Pharmacotherapy for Chemotherapeutic Induced Neurocognitive Decline

Carmen E Couvertier-Lebrón1, Pura Garcia-Serrablo1 and Summer F Acevedo2*
1Psychology Program, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico, USA
2Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, USA
Corresponding author : Summer F Acevedo
Department of Psychiatry, UT Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75235, USA
Tel: (214) 648-1170
E-mail:
[email protected]
Received: January 23, 2013 Accepted: August 16, 2013 Published: August 20, 2013
Citation: Couvertier-Lebrón CE, Garcia-Serrablo P, Acevedo SF (2013) Pharmacogenetics of Apolipoprotein E on Donepezil and Fluoxetine Pharmacotherapy for Chemotherapeutic Induced Neurocognitive Decline. J Womens Health, Issues Care 2:5. doi:10.4172/2325-9795.1000117

Abstract

Pharmacogenetics of Apolipoprotein E on Donepezil and Fluoxetine Pharmacotherapy for Chemotherapeutic Induced Neurocognitive Decline

Chemotherapeutic drugs are designed to target and kill cancer cells, but significant evidence indicates they also attack other cells including neurons, which in some cases leads to long-term neurocognitive deficits. The aim of this review is to examine the potential use of pharmacotherapy (Donepezil, Fluoxetine) as a preventive treatment to assist and manage the long-term cognitive effects of chemotherapeutic agents. Response to any type of medication is mixed; some individuals respond well to pharmacotherapies whereas others seem less responsive.

Keywords: ApoE; Donepezil; Fluoxetine; Pharmacotherapy; Cognition; Chemotherapy

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