Research Article, J Pharm Drug Deliv Res Vol: 1 Issue: 3
Preparation of Zaleplon Microparticles Using Emulsion Solvent Diffusion Technique
Ahmed Abd El-Bary1, Omaima El-Gazayerly1, Arwa El-Hagrasy1 and Ibtehal Salah Ad-din1* |
1Faculty of Pharmacy, Cairo University, Pharmaceutics and Industrial Pharmacy Department, Kasr El-aini street, Cairo 11562, Egypt |
2College of Pharmacy, Purdue University, Chemical Engineering, Indiana, USA |
Corresponding author : Salah Ibtehal Faculty of Pharmacy, Cairo University, Pharmaceutics and Industrial Pharmacy Department, Kasr El-aini Street, Cairo 11562, Egypt Tel: (20) 1111279857 E-mail: ibtehalsalah@ymail.com |
Received: September 18, 2012 Accepted: November 14, 2012 Published: November 19, 2012 |
Citation: Ibtehal S, Omaima EG, Arwa EH, Ahmed AB (2012) Preparation of Zaleplon Microparticles Using Emulsion Solvent Diffusion Technique. J Pharm Drug Deliv Res 1:3. doi:10.4172/2325-9604.1000108 |
Abstract
Preparation of Zaleplon Microparticles Using Emulsion Solvent Diffusion Technique
Zaleplon is a BCS class II drug suffering from poor solubility. In a trial to improve its dissolution, emulsion solvent diffusion method (ESD) was used to prepare zaleplon microparticles using sodium lauryl sulfate (SLS) as surfactant. Optimization of drug system was achieved. Particle size values of the prepared microparticles were ranged from 6.57 μm to 20.30 μm with narrow particle size distribution range. Differential scanning calorimetry (DSC) and x-ray diffraction (XRD) were used for the characterization of the prepared systems. DSC and XRD patterns showed that the zaleplon microparticles possessed decreased crystallinity. Dissolution studies demonstrated that the systemated zaleplon microparticles exhibited significantly enhanced dissolution rate when compared to pure zaleplon.