Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Research Article, J Pharm Drug Deliv Res Vol: 1 Issue: 3

Preparation of Zaleplon Microparticles Using Emulsion Solvent Diffusion Technique

Ahmed Abd El-Bary1, Omaima El-Gazayerly1, Arwa El-Hagrasy1 and Ibtehal Salah Ad-din1*
1Faculty of Pharmacy, Cairo University, Pharmaceutics and Industrial Pharmacy Department, Kasr El-aini street, Cairo 11562, Egypt
2College of Pharmacy, Purdue University, Chemical Engineering, Indiana, USA
Corresponding author : Salah Ibtehal
Faculty of Pharmacy, Cairo University, Pharmaceutics and Industrial Pharmacy Department, Kasr El-aini Street, Cairo 11562, Egypt
Tel: (20) 1111279857
E-mail: [email protected]
Received: September 18, 2012 Accepted: November 14, 2012 Published: November 19, 2012
Citation: Ibtehal S, Omaima EG, Arwa EH, Ahmed AB (2012) Preparation of Zaleplon Microparticles Using Emulsion Solvent Diffusion Technique. J Pharm Drug Deliv Res 1:3. doi:10.4172/2325-9604.1000108

Abstract

Preparation of Zaleplon Microparticles Using Emulsion Solvent Diffusion Technique

Zaleplon is a BCS class II drug suffering from poor solubility. In a trial to improve its dissolution, emulsion solvent diffusion method (ESD) was used to prepare zaleplon microparticles using sodium lauryl sulfate (SLS) as surfactant. Optimization of drug system was achieved. Particle size values of the prepared microparticles were ranged from 6.57 μm to 20.30 μm with narrow particle size distribution range. Differential scanning calorimetry (DSC) and x-ray diffraction (XRD) were used for the characterization of the prepared systems. DSC and XRD patterns showed that the zaleplon microparticles possessed decreased crystallinity. Dissolution studies demonstrated that the systemated zaleplon microparticles exhibited significantly enhanced dissolution rate when compared to pure zaleplon.

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