A study evaluating the role of malon-di-aldehyde in vitiligo

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Sinu Rose Mathachan
Dr. RML Hospital, India

Iran University of Medical Sciences, Iran

: J Clin Exp Dermatol Res

Abstract

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There are several ways by which oxidative stress is generated and is involved in the development of vitiligo. This study evaluated the role of malon-di-aldehyde (MDA) related to the oxidative stress pathway in patients with active and stable vitiligo with either localized or generalized disease. Aim of this study was to evaluate the serum levels of the oxidative stress parameter Malon-di-aldehyde (MDA) in patients of localized and generalized vitiligo and to correlate with the duration and activity of the disease. 60 clinically diagnosed vitiligo patients categorized into generalized (n = 30) or localized vitiligo (n = 30) and were further grouped according to their disease activity in to active and stable groups. Thirty healthy volunteers were included in the control group. ELISA was used for the evaluation of MDA. Patient group demonstrated significantly raised levels of MDA compared to the control group. Further, MDA was significantly more deranged in patients with the generalized vitiligo (157.23±212.197) than in those with localized (49.93±40.82) vitiligo (Figure 1). Also MDA was significantly more deranged in patients with disease activity (60.85± 54.44 in localised vitiligo/179.25± 242.89 in generalised vitiligo) than in those with stable disease (42.65 ± 27.99 in localised/96.68 ± 61.88 in generalised) (Figure 2,3). No significant association was noted in relation to the duration of the disease. Our findings suggest an essential role of free radical damage and oxidative stress in localized and generalized vitiligo. Further, this study also highlights that uncontrolled oxidative damage may be a contributory factor in causing progression to generalized disease. We noted the key role of MDA in the progression and activity of the disease

Biography

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Dr. Sinu Rose is currently working as Senior Resident in the Department of Dermatology, ABVIMS & Dr. RML hospital, a central government institution in New Delhi, India. She completed her postgraduation (2017-2020) from the same institute. She has been continuously involved in various research work in the areas of Dermatology. She has over 45 publications in PubMed indexed national and international journals, several oral/ poster presentations and have received scholarships to attend national and international conferences.