Green synthesis of heterocyclic compounds and asymmetric organocatalysis

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Wei Zhang

University of Massachusetts Boston, USA

: J Chem Appl Chem Eng

Abstract

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This presentation highlights our recent effort on the development of pot, atom, and step economy synthesis and asymmetric catalysis to maximize reaction. New reaction sequences of one-pot and multicomponent reactions have been developed for the synthesis of diverse heterocyclic scaffolds with substitution, skeleton, and stereochemistry variations. Recyclable organocatalyst-promoted cascade reactions have been introduced for asymmetric fluorination, Michael addition, Mannich reaction, Robinson annulation and other transformations to construct drug-like molecules with multiple stereocenters. Screening of our compounds for druggable targets such bromodomains, kinases, RORt, and HIV-1 will be mentioned.

Biography

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E-mail: wei2.zhang@umb.edu