Polymorphisms in the gene IL-1A are associated with chronic rhinosinusitis and associated phenotypes in Chinese population
Xu Yang, Cao Min, Ren Jianjun, Yang Wen, Wang Jing, Cheng Danni, Song Yao and Zhao Yu
Sichuan University, China
: J Otol Rhinol
Abstract
Background: The gene encoding IL-1A (Interleukin 1 alpha), a cytokine that processes metabolic, physiological and haematopoietic activities is localized on chromosome 2q14.1, where evidence for linkage to chronic rhinosinusitis has been previously reported in Caucasian. Objective: We hypothesized that variants in IL-1A are associated with chronic rhinosinusitis and related phenotypes in Chinese population. Three candidate SNPs (single nucleotide polymorphism) were involved in this study. Methods: We investigated the association between three single nucleotide polymorphisms throughout the IL-1A gene and chronic rhinosinusitis, the results of SNOT-22, Lund- Mackay CT scale, Lund-Kennedy endoscope scale among 576 chronic rhinosinusitis patients, 600 control polymorphisms of three SNP were also tested. Real-time PCR was used to assess whether IL-1A cDNA expression differed with IL-1A genotype. Results: Significant effects were observed for all three phenotypes and IL-1A markers (rs17561, rs2856838, rs1800587) by means of single-marker and haplotype analyses. Conclusion: Results indicate that polymorphisms in markers within the IL-1A gene are associated with risk of chronic rhinosinusitis. Strong relationship were observed between polymorphisms and results of SNOT-22, Lund-Mackay CT scale and Lund-Kennedy endoscope scale. Recent Publications 1. Xu Y, Zhao Y, Ren JJ, Wang J, Lei L and Zheng YB (2017) The advances of probiotics treatment of allergic rhinitis. Journal of Clinical Otorhinolaryngology, Head and Neck Surgery 31(17):1322-1327. 2. Ren J J, Zhao Y, Wang J, Ren X, Xu Y, Tang W and He Z (2017) PepsinA as a marker of laryngopharyngeal reflux detected in chronic rhinosinusitis patients. Otolaryngology Head and Neck Surgery 156(5):893- 900. 3. Wang J, Yu Z and Ren J (2017) Effects of pepsin A on heat shock protein 70 response in laryngopharyngeal reflux patients with chronic rhinosinusitis. Acta Otolaryngol. 137(12):1253-1259. 4. Wang J and Zhao Y (2018) Pepsin in saliva as a diagnostic biomarker in laryngopharyngeal reflux: a meta-analysis. Eur Arch Otorhinolaryngol. 275(3):671- 678.
Biography
Xu Yang has his expertise in evaluation and passion in improving the health and wellbeing. He has completed his M D and is pursuing his PhD. He has established animal models both in allergic rhinitis and laryngopharyngeal reflux. Currently, he is researching the single nucleotide polymorphism among many diseases in ENT.
E-mail: minotaur9212@qq.com
