Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Research Article,  J Pharm Drug Deliv Res Vol: 3 Issue: 2

Quality Control Testing and Equivalence of Doxycycline Hyclate (100 mg) Capsule Brands under Biowaiver Conditions

Rabia Humayoon1, Nighat Razvi1, Fakhsheena Anjum2*, Sana Ghayas2, Lubna Ghazal1, and Saeed Ahmad Siddiqui1
1Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Pakistan
2Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan
Corresponding author : Fakhsheena Anjum
Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan
E-mail: [email protected]
Received: February 19, 2014 Accepted: August 04, 2014 Published: August 07, 2014
Citation: Humayoon R, Razvi N, Anjum F, Ghayas S, Ghazal L, Siddiqui SA (2014) Quality Control Testing and Equivalence of Doxycycline Hyclate (100 mg) Capsule Brands under Biowaiver Conditions. J Pharm Drug Deliv Res 3:2. doi:10.4172/2325-9604.1000124

Abstract

 The study aimed to compare dissolution profiles of five generics of a BCS class I drug (Doxycycline Hyclate) with innovator Doxycycline Hyclate and also to compare the quality of different brands of Doxycycline Hyclate 100 mg capsules, collected from various retail pharmacies in the local market of Pakistan under biowaiver conditions. Assessment of physical parameters which include uniformity of weight and disintegration test was done according to British Pharmacopeia (BP) 2007 requirements. Chemical assay was carried out using a validated UV spectrophotometric method. 

Keywords: Bioequivalence; Biowaiver; Doxycycline Hyclate Capsules; Generic medicines.

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