Journal of Womens Health, Issues and Care ISSN: 2325-9795

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Research Article, J Womens Health Issues Care Vol: 2 Issue: 1

A Randomized Controlled Trial of the Effects of Retinyl Palmitate on CD4+ T Cell Related Cytokines, Thyroid Function and Metabolic Biomarkers in Obesity: A Study Design and Protocol

Mahdieh Abbasalizad Farhangi1, Ali-Akbar Saboor- Yaraghi2, Mohammadreza Eshraghian3, Alireza Ostadrahimi4 and Seyyed-Ali Keshavarz5*
1Department of Community Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Cellular and Molecular Nutrition, School of Nutrition and Dietetics, Tehran University of Medical sciences, Tehran, Iran
3Faculty of Public Health, Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran, Iran
4Nutrition Research Center, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
5Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
Corresponding author : Seyyed-Ali Keshavarz
Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Tel: +98 021 88954911; Fax: +98 021 88974462
Email: [email protected]
Received: December 06, 2012 Accepted: February 04, 2013 Published: February 08, 2013
Citation: Farhangi MA, Saboor-Yaraghi AA , Eshraghian M, Ostadrahimi A, Keshavarz SA (2013) A Randomized Controlled Trial of the Effects of Retinyl Palmitate on CD4+ T Cell Related Cytokines, Thyroid Function and Metabolic Biomarkers in Obesity: A Study Design and Protocol. J Womens Health, Issues Care 2:1. doi:10.4172/2325-9795.1000102

Abstract

A Randomized Controlled Trial of the Effects of Retinyl Palmitate on CD4+ T Cell Related Cytokines, Thyroid Function and Metabolic Biomarkers in Obesity: A Study Design and Protocol

Obesity, as a low grade chronic inflammatory condition, is associated with immune system dysfunction and several autoimmune diseases. Recent evidence demonstrates a pathogenic role for T-helper cells in developing obesity related immune-disorders. Vitamin A and its retinoid derivates are best known for their immune-regulatory effects. However, the effect of vitamin A supplementation on immune function in obese individuals is still unknown. The aim of the present study is to investigate the possible role of vitamin A supplementation on serum T-helper cytokines and several other secondary outcomes (anthropometric and metabolic parameters and thyroid function) in healthy obese reproductive age women

Keywords: Vitamin A; Obesity; T-Helpers; Thyroid hormones; Study protocol

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