Journal of Otology & RhinologyISSN: 2324-8785

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Research Article, J Otol Rhinol Vol: 4 Issue: 1

Relationship of Vitamin D Levels in Thyroid Malignancy

Matthew Marino1, Andrew M. Hinson1, Eric R. Siegel2, Jonathan W.Rutledge1, Donald L. Bodenner3,4 and Brendan C. Stack Jr.1,4*
1Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Arkansas, USA
2Department of Biostatistics, University of Arkansas for Medical Sciences,Arkansas, USA
3Department of Geriatrics, University of Arkansas for Medical Sciences, Arkansas,USA
4University of Arkansas for Medical Sciences Thyroid Center, Arkansas, USA
Corresponding author : Brendan C Stack Jr. MD
FACS, FACE, 4301 W. Markham St. #543, Little Rock, AR 722135
Tel: 501-686-5140; Fax: 501-686-8029
Received: May 06, 2014 Accepted: August 10, 2014 Published: January 28, 2014
Citation: Marino M, Hinson AM, Siegel ER, Rutledge J, Bodenner DL, et al. (2015) Relationship of Vitamin D Levels in Thyroid Malignancy. J Otol Rhinol 4:1. doi:10.4172/2324-8785.1000204


Relationship of Vitamin D Levels in Thyroid Malignancy

Vitamin D has been reported in several studies to have antiproliferative, anti-apoptotic and pro-differentiating effects in several tumor types. The role of vitamin D in the incidence and/or progression of thyroid malignancy remain largely unknown. We performed a retrospective chart review of postoperative 25-hydroxyvitamin D levels from 255 subjects receiving total (n=197) or completion (n=58) thyroidectomy for benign (n=190) and malignant (n=65) disease at the University of Arkansas for Medical Sciences between October 2005 and July 2013. No significant difference (P = 0.72) was observed between postoperative 25-hydroxyvitamin D levels in subjects with malignant pathology (median 25 ng/mL; range 21-37 ng/ml) versus benign pathology (median 27 ng/ml; range 19.5-35 ng/ml). In our limited study, there was no correlation between postoperative 25-hydroxyvitamin D status and pathological findings in subjects undergoing thyroidectomy.

Keywords: Thyroid cancer; Vitamin D deficiency; 25-hydroxyvitamin D

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