Journal of Veterinary Science & Medical Diagnosis ISSN: 2325-9590

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Research Article, J Vet Sci Med Diagn Vol: 3 Issue: 3

Sildenafil Efficacy on Renal Ischemia- Reperfusion Injury in Experimental Dogs

Esam Mosbah1, El- Sayed El- Shafaey1, Youssef El- Seady2, Walaa Awadin3* and Adel Zaghloul1
1Department of Surgery, Anaesthesiology and Radiology, Mansoura University, Mansoura, Egypt
2Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
3Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
Corresponding author : Dr. Walaa Awadin
Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
Tel: +201011610725; Fax: +20502379952
E-mail: [email protected]
Received: March 24, 2014 Accepted: June 09, 2014 Published: June 13, 2014
Citation: Mosbah E, El- Shafaey ES, El- Seady Y, Awadin W, Zaghloul A (2014) Sildenafil Efficacy on Renal Ischemia- Reperfusion Injury in Experimental Dogs. J Vet Sci Med Diagn 3:3. doi:10.4172/2325-9590.1000139

Abstract

 Sildenafil Efficacy on Renal Ischemia- Reperfusion Injury in Experimental Dogs

The present study reveals a catastrophic corrosive ingestion injury of upper gastrointestinal tract. A 17 year old boy intentionally ingested some corrosive acid and died due to perforation of stomach and peritonitis. The autopsy findings and toxicological analysis report confirmed that he had ingested sulphuric acid. A thorough literature review of corrosive ingestion injuries, their diagnosis and treatment allowed to show the fatality of such cases depend on the type and amount of corrosive ingested, the state of stomach whether empty or full, the promptness of treatment given and various such factors.

Keywords: Ischemia/reperfusion; Kidney; Histopathology; Apoptosis

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