Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Editorial, J Liver Dis Transplant Vol: 1 Issue: 1

Defining Single Nucleotide Polymorphic (SNP) Variants Role of Human Angiotensinogen in Liver Fibrosis

Rais A. Ansari*
College of Pharmacy, Nova Southeastern University, Florida, USA
Corresponding author : Rais A Ansari
Department of Pharmaceutical Sciences, College of Pharmacy, Health Professions Division, Terry Building, Rm 1344, Nova Southeastern University, 3200 S University Drive, Fort Lauderdale, FL 33328, USA
Tel: (954)-262-1344
E-mail: [email protected]
Received: June 07, 2012 Accepted: June 08, 2012 Published: June 10, 2012   doi:10.4172/2325-9612.1000e101
Citation: Rais A. Ansari, et al (2012) Defining Single Nucleotide Polymorphic (SNP) Variants Role of Human Angiotensinogen in Liver Fibrosis. J Liver:: Dis Transplant 1:1. doi:10.4172/2325-9612.1000e101

Abstract

Defining Single Nucleotide Polymorphic (SNP) Variants Role of Human Angiotensinogen in Liver Fibrosis

The sequencing of human genome has lead to define the variations among individuals, which is quite astonishing. With the advent of single nucleotide variants among genes, that is believed to be present in every 1.0 kb in human genome, determining the effects of these variants on biological process has been a daunting task. Utilizing the modern molecular biological techniques, the role(s) of the SNPs in promoter elements has been defined in several genes. However, the SNPs, which are part of the coding sequences of genes, have been difficult to define. Models to define the messenger RNA stability (Mfold analysis) have been developed. However, such a correlation in terms of end product as protein is still confusing. A number of attempts have been made to decipher the gene function of individual SNP variant, what is referred as “allelic expression variant” of haplotype as compared to wild type. In this context it is noteworthy that allelic variants have found to possess different activities.

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