Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Research Article, J Pharm Drug Deliv Res Vol: 2 Issue: 2

Solubility and Dissolution Enhancement of Candesartan Cilexetil by Liquisolid Compacts

Harika Puppala Satya Krishna1, Bharath Srinivasan1*, Deveswaran Rajamanickam1, Basavaraj Basappa Veerabhadraiah1 and Madhavan Varadharajan2
1Department of Pharmaceutics, M.S.Ramaiah College of Pharmacy, Bangalore-54, India
2Department of Pharmacognosy, M.S.Ramaiah College of Pharmacy, Bangalore-54, India
Corresponding author : Bharath Srinivasan
Department of Pharmaceutics, M.S. Ramaiah College of Pharmacy, M.S.R Nagar, M.S.R.I.T. Post, Bangalore - 560 054, Karnataka, India
E-mail: [email protected]
Received: February 18, 2012 Accepted: April 10, 2013 Published: April 15, 2013
Citation: Satya Krishna HP, Srinivasan B, Rajamanickam D, Veerabhadraiah BB, Varadharajan M (2013) Solubility and Dissolution Enhancement of Candesartan Cilexetil by Liquisolid Compacts. J Pharm Drug Deliv Res 2:2. doi:10.4172/2325-9604.1000115

Abstract

Solubility and Dissolution Enhancement of Candesartan Cilexetil by Liquisolid Compacts

Candesartan cilexetil belong to the class angiotensin-II receptor antagonist used in the treatment of hypertension. It is practically insoluble in water, belongs to a BCS class-II and its half life is 5.1 h with bioavailability of 15 - 40%. The aim of this study was to investigate the use of liquisolid technique in improving the dissolution profile of candesartan cilexetil. The liquisolid tablets were formulated using a non-volatile liquid vehicle PEG 400 at three drug concentrations of 40%, 50% and 60% w/w and at an excipient ratio of 10, 20 and 30 using methyl cellulose 4000 cps and dibasic calcium phosphate as carrier and coating material. The Angle of slide, Liquid load factor and Flowable liquid retention potential concepts were applied to calculate the amounts of carrier and coating material required to prepare candesartan cilexetil liquisolid tablets.

Keywords: Liquisolid compacts; Candesartan cilexetil; Carrier material;Coating material; Angle of slide; Flowable liquid retention potential; Liquid load factor

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