Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Research Article, J Pharm Drug Deliv Res Vol: 1 Issue: 2

Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Nonenzymatic Antioxidants in Testes and Brain of Male Rats

Akintunde JK1*, Ajiboye JA2, Siemuri EO3, Oyelowo SB2, Sunday OJ4, Abam EO2 and Irondi AE5
1College of Pure and Applied Sciences, Department of Biosciences and Biotechnology, Biochemistry unit (Drug Metabolism and Toxicology), Kwara State University, Malete, Ilorin, Nigeria
2Department of Chemical Sciences, Biochemistry unit, College of Natural and Applied Sciences, Bells University of Technology Ota, Ogun State, Nigeria
3Faculty of Basic Medical Sciences, Department of Biochemistry, Membrane Biochemistry and Biotechnology, University of Ibadan, Nigeria
4College of Pure and Applied Sciences, Department of Biosciences and Biotechnology, Plant and Environmental Biology unit, Kwara State University, Malete, Ilorin, Nigeria
4Functional Foods, Nutraceuticals and Phytomedicine Research Laboratory, Department of Biochemistry, Federal University of Technology, Akure, Nigeria
Corresponding author : Akintunde JK
College of Pure and Applied Sciences, Department of Biosciences and Biotechnology, Biochemistry unit (Drug metabolism and Toxicology), Kwara State University, Malete, Ilorin, Nigeria
Tel: +23408064156056; Fax: +23408064156056
E-mail: [email protected]
Received: August 24, 2012 Accepted: October 08, 2012 Published: October 10, 2012
Citation: Akintunde JK, Ajiboye JA, Siemuri EO, Oyelowo SB, Sunday OJ, et al. (2012) Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Non-enzymatic Antioxidants in Testes and Brain of Male Rats. J Pharm Drug Deliv Res 1:2. doi:10.4172/2325-9604.1000105

Abstract

Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Nonenzymatic Antioxidants in Testes and Brain of Male Rats

Sildenafil citrate, a specific phosphodiesterase-5 (PDE-5) inhibitor drug currently used for the treatment of erectile dysfunction in men. The present study investigates the effects of Sildenafil citrate on antioxidant defense systems of testes and brain tissues of male rats by measuring the GSH, SOD, and CAT activity. Lipid peroxidation was also estimated by measuring the MDA levels, a Thiobarbituric Acid Reactive Substrate (TBARS) as biomarker of oxidative stress. Sildenafil citrate was orally administered at the different dose levels of 20 mg/kg body weight per 30 days in four divided doses of 50, 100, 150 and 200 mg/kg body weight while control rats were given distilled water.

Keywords: Sildenafil citrate; Antioxidant defense system; MDA;Testes; Brain

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