Research Article, J Pharm Drug Deliv Res Vol: 1 Issue: 2
Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Nonenzymatic Antioxidants in Testes and Brain of Male Rats
Akintunde JK1*, Ajiboye JA2, Siemuri EO3, Oyelowo SB2, Sunday OJ4, Abam EO2 and Irondi AE5 | |
1College of Pure and Applied Sciences, Department of Biosciences and Biotechnology, Biochemistry unit (Drug Metabolism and Toxicology), Kwara State University, Malete, Ilorin, Nigeria | |
2Department of Chemical Sciences, Biochemistry unit, College of Natural and Applied Sciences, Bells University of Technology Ota, Ogun State, Nigeria | |
3Faculty of Basic Medical Sciences, Department of Biochemistry, Membrane Biochemistry and Biotechnology, University of Ibadan, Nigeria | |
4College of Pure and Applied Sciences, Department of Biosciences and Biotechnology, Plant and Environmental Biology unit, Kwara State University, Malete, Ilorin, Nigeria | |
4Functional Foods, Nutraceuticals and Phytomedicine Research Laboratory, Department of Biochemistry, Federal University of Technology, Akure, Nigeria | |
Corresponding author : Akintunde JK College of Pure and Applied Sciences, Department of Biosciences and Biotechnology, Biochemistry unit (Drug metabolism and Toxicology), Kwara State University, Malete, Ilorin, Nigeria Tel: +23408064156056; Fax: +23408064156056 E-mail: akintundejacob@yahoo.com |
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Received: August 24, 2012 Accepted: October 08, 2012 Published: October 10, 2012 | |
Citation: Akintunde JK, Ajiboye JA, Siemuri EO, Oyelowo SB, Sunday OJ, et al. (2012) Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Non-enzymatic Antioxidants in Testes and Brain of Male Rats. J Pharm Drug Deliv Res 1:2. doi:10.4172/2325-9604.1000105 |
Abstract
Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Nonenzymatic Antioxidants in Testes and Brain of Male Rats
Sildenafil citrate, a specific phosphodiesterase-5 (PDE-5) inhibitor drug currently used for the treatment of erectile dysfunction in men. The present study investigates the effects of Sildenafil citrate on antioxidant defense systems of testes and brain tissues of male rats by measuring the GSH, SOD, and CAT activity. Lipid peroxidation was also estimated by measuring the MDA levels, a Thiobarbituric Acid Reactive Substrate (TBARS) as biomarker of oxidative stress. Sildenafil citrate was orally administered at the different dose levels of 20 mg/kg body weight per 30 days in four divided doses of 50, 100, 150 and 200 mg/kg body weight while control rats were given distilled water.