Journal of Otology & RhinologyISSN: 2324-8785

Reach Us +1 850 754 6199

Research Article, J Otol Rhinol Vol: 3 Issue: 5

Volume Expansion of Tissue Engineered Human Nasal Septal Cartilage

Marsha S Reuther1,2*, Kristen K Briggs3,4, Monica K Neuman5,Koichi Masuda6, Robert L Sah3 and Deborah Watson1,2
1Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA
2Head and Neck Surgery Section, VA San Diego Healthcare System, San Diego,California, USA
3Department of Bioengineering, University of California, San Diego, La Jolla,California, USA
4Research Service, VA San Diego Healthcare System, San Diego, California, USA
5Creighton University School of Medicine, Omaha, Nebraska, USA
6Department of Orthopedic Surgery, University of California, San Diego, La Jolla,California, USA
Corresponding author : Marsha Reuther
University of California, San Diego, Division of Otolaryngology-Head and Neck Surgery, 3350 La Jolla Village Drive, 112-C, San Diego, CA 92161, USA
Tel: 858-642-3405; Fax: 858-552-7466
E-mail: [email protected]
Received: May 18, 2014 Accepted: June 29, 2014 Published: July 10, 2014
Citation: Marsha S Reuther, Kristen K Briggs, Monica K Neuman, Koichi Masuda, Robert L Sah, Deborah Watson (2014) Volume Expansion of Tissue Engineered Human Nasal Septal Cartilage. J Otol Rhinol 3:4. doi:10.4172/2324-8785.1000172

Abstract

Volume Expansion of Tissue Engineered Human Nasal Septal Cartilage

Importance: Cartilaginous craniofacial defects range in size and autologous cartilaginous tissue is preferred for repair of these defects. Therefore, it is important to have the ability to produce large size cartilaginous constructs for repair of cartilaginous abnormalities.

Objectives: 1. To produce autologous human septal neocartilage constructs substantially larger in size than previously produced constructs 2. To demonstrate that volume expanded neocartilage constructs possess comparable histological and biochemical properties to standard size constructs 3. To show that volume expanded neocartilage constructs retain similar biomechanical properties to standard size constructs.

Design: Prospective, basic science.

Setting: Laboratory

Participants: The study used remnant human septal specimens removed during routine surgery at the University of California, San Diego Medical Center or San Diego Veterans Affairs Medical Center. Cartilage from a total of 8 donors was collected.

Keywords: Cartilage tissue engineering; Human septal cartilage; Cartilage construct

Track Your Manuscript

Share This Page

Media Partners

Associations