Clinical Oncology: Case Reports

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

68Ga-DOTANOC PET-CT is a Valuable Tool for Diagnosing an Optic Nerve Sheath Meningioma-A Case Report and Literature Review

Background: Optic nerve sheath meningiomas (ONSM) are one of the most common tumors affecting the optic nerve. Since operative decompression is known to cause visual loss, a biopsy diagnosis is usually unavailable. Though high-resolution MRI can delineate the tumor extent well, another reliable, non-invasive diagnostic method is desirable. Most meningiomas express somatostatin receptors and PET tracers based on ligands such as 68Ga-DOTATATE have high sensitivity in detecting them.

Observations:  We describe the clinical presentation of a patient who presented with a history of recently noticed visual loss. We describe the imaging findings in MRI and the confirmation of the diagnosis with a 68Ga-DOTANOC PET scan before we decided on radiation therapy.  The lesion was distinctly seen within the intraorbital area with a maximum standardized uptake value of  2.77. We also review the literature which compares the utility of this modality in comparison to MRI in ruling out alternative diagnoses.

Lessons: Imaging with somatostatin receptor ligands like 68Ga-DOTANOC is a valuable tool in the non-invasive diagnosis of orbital lesions. It helps in differentiating meningiomas from other benign and malignant conditions. 68Ga-DOTANOC scan should be considered in all patients with equivocal imaging findings in meningiomas.

Special Features

Full Text


Track Your Manuscript

Media Partners