Case Report, Clin Oncol Case Rep Vol: 4 Issue: 8
68Ga-DOTANOC PET-CT is a Valuable Tool for Diagnosing an Optic Nerve Sheath Meningioma-A Case Report and Literature Review
Senthamizhan Sundaramoorthy1, Shyama Prem S1, Dhanapathi Halanaik2, Nirupama Kasturi3, Krishnan Nagarajan4, Sunitha Vellathussery Chakkalakkoombil4, and Gopalakrishnan Madhavan Sasidharan5*
1Department of Radiation Oncology, Regional Cancer Center, JIPMER, Puducherry, India
2Department of Nuclear medicine, JIPMER, Puducherry, India
3Department of Ophthalmology, JIPMER, Puducherry, India
4Department of Radiodiagnosis, JIPMER, Puducherry, India
5Department of Neurosurgery, JIPMER, Puducherry, India
*Corresponding Author :
Department of Neurosurgery
JIPMER, Puducherry, India
Received: June 30, 2021 Accepted: August 20, 2021 Published: August 27, 2021
Citation: Sundaramoorthy S, Prem SS, Halanaik D, Kasturi N, Nagarajan K, et al. (2021) 68Ga-DOTANOC PET-CT is a Valuable Tool for Diagnosing an Optic Nerve Sheath Meningioma-A Case Report and Literature Review. Clin Oncol Case Rep 4:8.
Background: Optic nerve sheath meningiomas (ONSM) are one of the most common tumors affecting the optic nerve. Since operative decompression is known to cause visual loss, a biopsy diagnosis is usually unavailable. Though high-resolution MRI can delineate the tumor extent well, another reliable, non-invasive diagnostic method is desirable. Most meningiomas express somatostatin receptors and PET tracers based on ligands such as 68Ga-DOTATATE have high sensitivity in detecting them.
Observations: We describe the clinical presentation of a patient who presented with a history of recently noticed visual loss. We describe the imaging findings in MRI and the confirmation of the diagnosis with a 68Ga-DOTANOC PET scan before we decided on radiation therapy. The lesion was distinctly seen within the intraorbital area with a maximum standardized uptake value of 2.77. We also review the literature which compares the utility of this modality in comparison to MRI in ruling out alternative diagnoses.
Lessons: Imaging with somatostatin receptor ligands like 68Ga-DOTANOC is a valuable tool in the non-invasive diagnosis of orbital lesions. It helps in differentiating meningiomas from other benign and malignant conditions. 68Ga-DOTANOC scan should be considered in all patients with equivocal imaging findings in meningiomas.