Current Status of Gadolinium Retention in the Brain

Gadolinium (Gd3+) based contrast agents previously demonstrated safe administration and were associated with minimal events of adverse reactions until NSF and gadolinium deposits were found in the brain. Gadolinium is a paramagnetic earth lanthanoid element with a ferromagnetic property that is suitable for intravenous administration. Recently, a series of studies raised their concern over the higher risk of developing NSF when administering nonionic linear agents such as gadodiamide and gadoversetamide