Journal of Forensic Toxicology & PharmacologyISSN: 2325-9841

Reach Us +1-209-730-0872
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassius auratus auratus)

Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassius auratus)

The pharmacokinetic of norfloxacin (10 mg kg-1) following single intravenous (IV) and oral administration (PO) in healthy goldfish were investigated. Also, repeated (PO) administration of norfloxacin in healthy and experimentally Aeromonas hydrophilia infected goldfish was studied. Following IV administration, norfloxacin obeyed a two compartments open model, distribution half-life (t1/2(α)) equal to 0.12 h, volume of distribution (Vdss) was 1.01 L kg-1, elimination halflife (t1/2(β)) was 4.30 h and total body clearance (CLtot) was 0.17 L kg-1h-1. Following PO administration, norfloxacin was rapidly and efficiently absorbed through gastrointestinal tract as the absorption half-life (t1/2(ab)) was 0.84 h.

Special Features

Full Text

View

Track Your Manuscript

Share This Page

Media Partners

Associations