Journal of Forensic Toxicology & PharmacologyISSN: 2325-9841

Reach Us +1-209-730-0872
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, J Forensic Toxicol Pharmacol Vol: 3 Issue: 1

Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassius auratus auratus)

Mohamed Aboubakr1*, Abdelazem Mohamed Abdelazem1 and Ashraf Mohamed Abdellatif2
1Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Qaliobiya, Egypt
2Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Qaliobiya, Egypt
Corresponding author : Dr. Mohamed Aboubakr
Department of pharmacology, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Qaliobiya, Egypt
Tel: +201099874671; Fax: +20132463074
E-mail: [email protected]; [email protected]
Received: November 28, 2013 Accepted: March 11, 2014 Published: March 18, 2014
Citation: Aboubakr M, Abdelazem AM, Abdellatif A (2014) Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassuys auratus Linnaeus). J Forensic Toxicol Pharmacol 3:1. doi:10.4172/2325-9841.1000115

Abstract

Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassius auratus)

The pharmacokinetic of norfloxacin (10 mg kg-1) following single intravenous (IV) and oral administration (PO) in healthy goldfish were investigated. Also, repeated (PO) administration of norfloxacin in healthy and experimentally Aeromonas hydrophilia infected goldfish was studied. Following IV administration, norfloxacin obeyed a two compartments open model, distribution half-life (t1/2(α)) equal to 0.12 h, volume of distribution (Vdss) was 1.01 L kg-1, elimination halflife (t1/2(β)) was 4.30 h and total body clearance (CLtot) was 0.17 L kg-1h-1. Following PO administration, norfloxacin was rapidly and efficiently absorbed through gastrointestinal tract as the absorption half-life (t1/2(ab)) was 0.84 h.

Keywords:

Track Your Manuscript

Share This Page