Monitoring and Validation of Tamoxifen by HPLC/DAD Method Assay

Objective: Tamoxifen (TAM) is the hormone therapy of choice in pre-menopausal estrogen receptor positive breast cancer in women, Therapeutic Drug Monitoring (TDM) of TAM may be clinically useful for guiding treatment decisions to optimize the efficacy and minimize occurrence of effects toxic side of this drug. The object if of this study is to develop and validate a simple chromatographic method for determination of TAM in human plasma.