Serum response of cortisol and Troponin-I to endurance exercise and electrical stimulation in myocardial infarction rats
Background and Aim: Due to the high prevalence of myocardial infarction and an increase in deaths caused by it by 2030, it is essential to provide alternative therapies. The aim of the present study was to investigate the serum response of CORT and cTnI to endurance exercise and electrical stimulation in myocardial infarction rats.
Materials and Methods: This experimental study was conducted with post-test design and with a control group. After induction of infarction with two subcutaneous injections of isoproterenol (150 mg / kg), 50 Wistar rats (8 weeks with a weight of 230 ± 30 g) were randomly divided into 5 groups of healthy, infarction, infarction-endurance exercise, infarction-electrical stimulation, and infraction-endurance exercise-electrical stimulation. The intervention groups received electrical stimulation for one session (foot shock device with a current intensity of 0.5 mA and a duration of 20 min) and endurance exercise (treadmill at a speed of 20 m / min for 1 h). Immediately after the intervention, serum levels of CORT and cTnI were measured. ANOVA and Tukey tests were used to analyze the data at a significance level of P <0.05.
Results: The results showed that myocardial infarction significantly increased serum levels of CORT and cTnI (P <0.0001). Also, the concentration of CORT in endurance exercise groups (P = 0.0008), electrical stimulation (P = 0.032) and endurance exercise-electrical stimulation (P = 0.044) showed a significant reduction compared to myocardial infarction group. Also, cTnI concentration in endurance exercise group showed a significant reduction compared to myocardial infarction group (P = 0.013).
Conclusion: It seems that endurance exercise and electrical stimulation individually and in combination with each other can result in an improvement in the conditions of myocardial infarction patients by reducing the concentration of CORT and cTnI