Sustained Drug Delivery in Pharmaceutical Dosage Forms for Novel Approaches of Formulation Design

Dosage form design involves the administration of API to achieve corrective or remedial effects on humans in the pharmaceutical field. Medication delivery technology consists of two main categories: Customary or standard medicament delivery devices and novel formulation technology for sustained medicament administration. Depending upon the formulation pattern, fluctuations in the API concentration may occur in serum level due to the direct release of medicament(s) from standard dosage forms. To maintain the steady-state concentration of API in serum level within the therapeutic window according to biopharmaceutics and pharmacokinetics, novel formulation delivery devices are advanced and modern technologies for controlled/sustained action for remedial or restorative response and these devices are also applicable for targeting at specific sites. Currently, sustained medicament administration is designed or framed to lessen or reduce undesired toxic effects as well as gastrointestinal irritation. The merit of this formulation design is that it is helpful for monitoring the dosing pattern and simultaneously lessens fluctuations in circulating the medicament concentrations in serum. Due to lower bulk density of gastro retentive devices lower than gastric fluid which float in gastric fluid and increase the residence time so that floating mechanism can be improved. Parenteral repository technique influences the sustainable delivery for the medicament via different nano formulation which also acts as a reservoir type of devices. Chrono-therapeutic is the novel technology for the administration of medicament at the right time, right dose for increase therapeutic efficacy with the design of microfabrication and 3D printing technology.