The Role of Euphol, a Tetracyclic Triterpene Possible Potential as Anti-Cancer with Computational Evidence (In-silico Insight)

Cancer-related death and morbidity are largely attributable to its widespread proliferation and invasiveness, which disrupts the normal functions of affected organs. Natural therapies such as plants have been used to treat cancer. Cancer can develop resistance to anticancer drugs over time, leading to treatment failure and tumor recurrence. A tetracyclic triterpene alcohol, euphol from Euphorbia. Tirucalli sap, contain anti-inflammatory, antiviral, and analgesic properties. This review article mainly accentuated the different anticancer perspectives of euphol like breast cancer, pancreatic cancer, glioma cell line, and gastric cancer. In this review, we described on the possible effect of euphol in cancer prevention in in vitro assays and techniques such as cell viability/proliferation, apoptosis, cellular senescence, invasion and migration, oxidative stress and antioxidant effects, gene and protein expression, and angiogenesis in cancer drug discovery. Furthermore, role of bioactive compound (euphol) against cancer analyzed through network pharmacology (ADME, Networking and Docking). Kegg analysis showed euphol is effective through different cancer pathways. Docking analysis performed by receptor protein 7aei and 7aem that have best fit with the compound: With docking scores of −8.8 and -8.6 respectively. In conclusion, euphol can be characterized as novel compound in drug development. The current review summarizes the most recent investigation of euphol.