Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604

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Alexis Goebel Author

AlexisGoebel@GMAIL.COM

Subjects of specialization
Vitamin E; Free surface electrospinning; Bioavailability; Drug solubility; Active Pharmaceutical ingredient; Pharmaceutical technology

Affiliation
Department of Chemical and Materials Engineering, California State Polytechnic University, Pomona

Biography

Alexis Goebel Department of Chemical and Materials Engineering, California State Polytechnic University, Pomona                                                   

Publications

Research Article Subscription

Free Surface Electrospinning of Microemulsions Containing Vitamin E

Author(s):

Jeffrey T. Miller, Alexis Goebel, Matthew Lee and Keith M. Forward

In research and development of pharmaceutical products, an estimated 90% of active pharmaceutical ingredients (APIs) are insoluble or partially soluble in water. Due to poor solubility, these APIs exhibit poor bioavailability in solid dosage forms. To improve the release rate of APIs, free surface electrospinning of a microemulsion was considered as a means of producing submicron size domains of API dispersed in an amorphous excipient. Microemulsions containing a poor solubility API, vitamin E, and an excipient, Polyvinylpyrrolidone, are electrospun to produce a highly porous material with a high surface area, which promotes rapid drug release. The materials were characterized by scanning electron microscopy and high performance liquid chromatography to dete... view more»

DOI: 10.4172/2325-9604.1000157

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