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Hindi Journal of Pharmaceutical Sciences & Emerging DrugsISSN: 2380-9477
Azza A Mahmoud Author
Subjects of specialization
Affiliation
Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Drag reduction, Drug Therapy
Department of Pharmaceutics & Pharmaceutical Technology, Future University, Cairo, Egypt.
Biography
Azza A Mahmoud; Department of Pharmaceutics & Pharmaceutical Technology, Future University, Cairo, Egypt. Keywords: Adverse Drug Reactions,Drug Action,Drug Delivery,Drug Discovery,Drug interaction,Drug Intoxication,Drug Therapy; Drug Transport and Delivery, Emerging Drugs, Medicinal Chemistry, Pharmaceutical Analysis, Pharmaceutical Design, Pharmaceutical Sciences, Pharmaceutics and Drug Design, Pharmacoepidemiological Studies, Pharmacognosy, Pharmacology
Publications
Research Article
Hydroxypropyl-Beta-Cyclodextrin as Cryoprotectant in Nanoparticles Prepared By Nano-Spray Drying Technique
Author(s): Amr Maged, Azza A Mahmoud and Mahmoud M Ghorab
Nano-spray dryer is advanced instrument to produce a stable and spherical nanoparticles with high yield. In this study, econazole nitrate nanoparticles were formulated by nano-spray dryer using 1:1, 1:2 and 1:3 weight ratios of drug to hydroxypropyl-betacyclodextrin and stabilizer. The prepared samples were sprayed through nozzle size of 7.0 μm using 95ºC and 45ºC as inlet temperature and outlet temperatures, respectively. The prepared nanoparticles were evaluated for process yield and percent drug loading. Furthermore, the drug nanoparticles were dispersed in isotonic buffer solution and examined for drug release and their stability at room temperature. The spray dried particles were in the nano-range (148 to 294 nm) and their yield values rang... view more»
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